Ji Ming, Fu Yongchao, Wan Xinglin, Du Xin
Department of Health Management Center, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Int Urol Nephrol. 2023 Jun;55(6):1641-1644. doi: 10.1007/s11255-023-03497-1. Epub 2023 Feb 3.
Normative distribution of serum cystatin C and relationship with sex and age in healthy adult Chinese population is unknown.
This is a prospective cohort study. Adult subjects (18 years of age and older) who underwent annual health examination at the Health Management Center in Sir Run Run Hospital were eligible. Subjects with major diseases, e.g., hypertension, diabetes, chronic kidney disease, obesity (body mass index ≥ 28 kg/m) were excluded from the analysis. Multivariate logistic regression analysis was conducted to identify risk factors of elevated cystatin C (> 1.03 mg/L). Data are shown as median and 95% confidence interval (CI).
The final analysis included a total of 10,640 subjects (40 ± 12 years, 52% men). The median serum cystatin C concentration was 0.73 mg/L (95% CI 0.52-1.03 mg/L) in the overall analysis, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. In the multivariate regression analysis, elevated cystatin C was independently associated with the male sex (odds ratio 1.94; 95% CI 1.07-3.52), older age (odds ratio 1.04 every year; 95% CI 1.02-1.06), higher body mass index (odds ratio 1.70; 95% CI 1.01-2.83), uric acid (odds ratio 1.00; 95% CI 1.00-1.01), and β2-microglobulin (odds ratio 39.35; 95% CI 22.90-67.64).
The median serum cystatin C concentration was 0.73 (95% CI 0.52-1.03 mg/L) in healthy adult Chinese population, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. Elevated cystatin C was associated with the male sex, older age and higher body mass index.
中国健康成年人群血清胱抑素C的规范分布及其与性别和年龄的关系尚不清楚。
这是一项前瞻性队列研究。符合条件的成年受试者（18岁及以上）为在邵逸夫医院健康管理中心接受年度健康检查者。分析排除患有重大疾病的受试者，如高血压、糖尿病、慢性肾病、肥胖（体重指数≥28kg/m）。进行多因素逻辑回归分析以确定胱抑素C升高（>1.03mg/L）的危险因素。数据以中位数和95%置信区间（CI）表示。
最终分析共纳入10640名受试者（40±12岁，52%为男性）。总体分析中血清胱抑素C浓度中位数为0.73mg/L（95%CI 0.52 - 1.03mg/L），男性为0.79（95%CI 0.59 - 1.07mg/L），女性为0.67（95%CI 0.49 - 0.95mg/L）。在多因素回归分析中，胱抑素C升高与男性（比值比1.94；95%CI 1.07 - 3.52）、年龄较大（每年比值比1.04；95%CI 1.02 - 1.06）、较高的体重指数（比值比1.70；95%CI 1.01 - 2.83）、尿酸（比值比1.00；95%CI 1.00 - 1.01）以及β2-微球蛋白（比值比39.35；95%CI 22.90 - 67.64）独立相关。
中国健康成年人群血清胱抑素C浓度中位数为0.73（95%CI 0.52 - 1.03mg/L），男性为0.79（95%CI 0.59 - 1.07mg/L），女性为0.67（95%CI 0.49 - 0.95mg/L）。胱抑素C升高与男性、年龄较大和较高的体重指数相关。
