Peselow E D, Goldring N, Barouche F, Fieve R R
Psychopathology. 1985;18(4):206-11. doi: 10.1159/000284406.
75 outpatients who presented to an affective disorder clinic received the dexamethasone suppression test (DST). Following 1 week observation, and following 1 week on low-dose imipramine HCl, all patients who remained depressed (Hamilton score 16 or greater) were given a full clinical trial of imipramine HCl (150-300 mg/day) over a minimum 3- to 5-week period. Of the 45 patients who required this trial and who received imipramine HCl for at least 3 weeks, there was no relationship between DST suppression or nonsuppression vs. clinical response to imipramine HCl. There was a statistically significant trend for suppressors (negative DST) to respond either spontaneously or to low-dose imipramine HCl as opposed to nonsuppressors (positive DST).
75名到情感障碍门诊就诊的门诊患者接受了地塞米松抑制试验（DST）。经过1周的观察，以及在服用低剂量盐酸丙咪嗪1周后，所有仍处于抑郁状态（汉密尔顿评分16分或更高）的患者在至少3至5周的时间内接受了盐酸丙咪嗪（150 - 300毫克/天）的全面临床试验。在45名需要进行该试验且接受盐酸丙咪嗪治疗至少3周的患者中，DST抑制或未抑制与对盐酸丙咪嗪的临床反应之间没有关联。与非抑制者（DST阳性）相比，抑制者（DST阴性）有自发反应或对低剂量盐酸丙咪嗪有反应的统计学显著趋势。
