Poland R E, Rubin R T, Lesser I M
Department of Psychiatry, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Biol Psychiatry. 1988 Apr 1;23(7):705-10. doi: 10.1016/0006-3223(88)90054-6.
The 1.0-mg Dexamethasone (DEX) Suppression Test (DST) was performed in 10 endogenous depressives prior to treatment, during treatment, and again when the patients were medication- and symptom-free. Five of the 10 patients were DST escapers prior to treatment, and all 10 patients were DST suppressors following treatment. During treatment, 6 patients were DST escapers, 2 of them having been suppressors initially. There were no significant differences in serum DEX concentrations before, during, and after treatment in either the 5 DST escapers or the 5 DST suppressors. These results lend further support to the concept that reduced serum DEX concentrations are not the major factor underlying DST nonsuppression.
对10名内源性抑郁症患者在治疗前、治疗期间以及患者停药且无症状时进行了1.0毫克地塞米松（DEX）抑制试验（DST）。10名患者中有5名在治疗前是DST逃逸者，治疗后所有10名患者均为DST抑制者。治疗期间，6名患者为DST逃逸者，其中2名最初是抑制者。5名DST逃逸者和5名DST抑制者在治疗前、治疗期间和治疗后的血清DEX浓度均无显著差异。这些结果进一步支持了血清DEX浓度降低不是DST不被抑制的主要因素这一观点。
