Dsouza Vinolyn, Jayaraman Jyothi, Loganathan Eswari, Ariadka Preethi Rai, Pai Chandana, Martis Jacintha, Monteiro Rochelle Cheryl, Shetty Prajna
Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Mangalore, Karnataka, India.
Department of Dermatology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
Pediatr Dermatol. 2025 Sep 2. doi: 10.1111/pde.70017.
Cutaneous Rosai-Dorfman disease (CRDD) is a rare non-Langerhans cell histiocytosis that mimics various granulomatous and neoplastic dermatoses, often leading to misdiagnosis. We report an 18-year-old male with a 13-year history of progressively enlarging erythematous plaques over the nasal bridge and right forearm, initially diagnosed as granulomatous inflammation. Histopathological examination revealed emperipolesis only after meticulous serial sectioning, and immunohistochemistry confirmed the diagnosis of CRDD. This case underscores the diagnostic challenges of CRDD, particularly in regions endemic for tuberculosis and leprosy, and highlights the importance of thorough histopathological and immunohistochemical evaluation in differentiating it from other dermatoses.
皮肤型罗萨伊-多夫曼病（CRDD）是一种罕见的非朗格汉斯细胞组织细胞增多症，可模仿各种肉芽肿性和肿瘤性皮肤病，常导致误诊。我们报告一名18岁男性，鼻梁和右前臂有逐渐增大的红斑性斑块，病史13年，最初被诊断为肉芽肿性炎症。组织病理学检查仅在经过细致的连续切片后才发现吞噬现象，免疫组织化学检查确诊为CRDD。该病例强调了CRDD的诊断挑战，尤其是在结核病和麻风病流行地区，并突出了全面的组织病理学和免疫组织化学评估在将其与其他皮肤病鉴别诊断中的重要性。
