Minter Daniel J, Chow Felicia C
Division of Infectious Diseases, University of California - San Francisco, San Fracisco, California, USA.
Weill Institute for Neurosciences, Department of Neurology, University of California - San Francisco, San Fracisco, California, USA.
Ann Neurol. 2025 Nov;98(5):1070-1076. doi: 10.1002/ana.78016. Epub 2025 Sep 2.
Neurosyphilis remains an important and highly morbid neurologic infection. Recent years have seen a dramatic increase in the incidence of syphilis across a variety of populations, making recognition of the many neurologic complications of this infection still relevant for modern clinicians. As manifestations of neurosyphilis are famously varied, a high index of suspicion is essential, especially in the face of atypical presentations. In this review, we discuss updates to the epidemiology, range of clinical presentations, diagnosis, and management of neurosyphilis. ANN NEUROL 2025;98:1070-1076.
神经梅毒仍然是一种重要且具有高度致病性的神经感染性疾病。近年来，梅毒在各类人群中的发病率急剧上升，因此认识这种感染的多种神经并发症对现代临床医生而言仍具有重要意义。由于神经梅毒的表现极为多样，高度的怀疑指数至关重要，尤其是面对非典型表现时。在本综述中，我们讨论神经梅毒在流行病学、临床表现范围、诊断和管理方面的最新进展。《神经病学年鉴》2025年；98:1070 - 1076。
