Warsh J J, Hasey G, Cooke R G, Stancer H C, Persad E, Jorna T, Godse D D
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):661-4. doi: 10.1016/0278-5846(85)90036-3.
Urinary and plasma DHPG and MHPG were estimated in patients with MADD and showing DST non-suppression as compared to those with normal suppression. Day and night 12h urine collections and morning plasma samples were analyzed by GC-MS for total MHPG and DHPG and free MHPG levels. Urinary DHPG excretion was significantly elevated in DST non-suppressors compared to suppressors, but no differences were found in urinary MHPG or plasma glycol levels. Elevated DHPG excretion in DST non-suppressors suggests that increased peripheral sympathetic NE activity occurs in association with dexamethasone resistance in MADD.
