尿3,4-二羟基苯乙二醇（DHPG）测量的效用研究。

Studies on the utility of urinary 3,4-dihydroxyphenylethylene-glycol (DHPG) measurement.

作者信息

Li P P, Warsh J J, Godse D D, Guttman M

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):717-20. doi: 10.1016/0278-5846(85)90047-8.

Abstract

The utility of urinary DHPG measurement as an index of NE function was evaluated in an animal model by determining its excretion following pharmacological manipulations that are known to alter noradrenergic activity. Acute desipramine (DMI) administration (10 mg/kg, i.p., b.i.d.) significantly reduced urinary DHPG (-26%) but not MHPG (-18%) excretion. Acute yohimbine administration (5 mg/kg, i.p., b.i.d.) significantly increased urinary DHPG and MHPG levels to a similar extent (+46%). These findings suggest that urinary DHPG levels also provide a sensitive indicator reflecting changes in NE neuronal activity. Further, DHPG may be a better measure of NE metabolism than MHPG to assess the efficiency of the NE neuronal uptake system.

摘要

通过测定已知会改变去甲肾上腺素能活性的药理学操作后的排泄情况，在动物模型中评估了尿中3,4-二羟基苯乙二醇（DHPG）测量作为去甲肾上腺素（NE）功能指标的效用。急性给予地昔帕明（DMI）（10mg/kg，腹腔注射，每日两次）显著降低了尿中DHPG排泄量（-26%），但未降低3-甲氧基-4-羟基苯乙二醇（MHPG）排泄量（-18%）。急性给予育亨宾（5mg/kg，腹腔注射，每日两次）显著增加了尿中DHPG和MHPG水平，且增加幅度相似（+46%）。这些发现表明，尿中DHPG水平也是反映NE神经元活动变化的一个敏感指标。此外，在评估NE神经元摄取系统的效率方面，DHPG可能比MHPG是更好的NE代谢指标。