Kavaliers M, Ossenkopp K P
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):713-6. doi: 10.1016/0278-5846(85)90046-6.
It has been previously demonstrated that weak fluctuating magnetic fields can act as environmental specific cues for the development of tolerance to morphine-induced analgesia in mice. During the course of this tolerance development the basal nociceptive response of the animals preexposed to magnetic fields are also increased. The magnetic field-induced increase in the basal nociceptive response can be blocked by the opiate antagonist, naloxone, suggesting an opioid-mediated stress effect of the magnetic stimuli. It is suggested that part of the actions of the magnetic stimuli as environmental specific stimuli may arise through their actions as stressors during the tolerance acquisition phase, as well as from their effects on opioid systems.
先前已经证明，微弱的波动磁场可以作为环境特异性线索，影响小鼠对吗啡诱导的镇痛产生耐受性。在这种耐受性形成过程中，预先暴露于磁场的动物的基础伤害性反应也会增强。磁场诱导的基础伤害性反应增强可被阿片拮抗剂纳洛酮阻断，这表明磁刺激存在阿片介导的应激效应。有人认为，磁刺激作为环境特异性刺激的部分作用，可能源于其在耐受性获得阶段作为应激源的作用，以及对阿片系统的影响。
