Morozova A S, Zvartau E E
Pharmacol Biochem Behav. 1986 Sep;25(3):533-6. doi: 10.1016/0091-3057(86)90136-x.
Components of complex emotional reaction to nociceptive stimulation as well as antinociceptive effect of periaqueductal gray matter (PAG) electrical stimulation were determined in rats. Animals were treated with morphine hydrochloride or saline for 10 days. Morphine analgesic effect during subchronic dosage (50 mg/kg a day) was gradually decreased. The same was true for stimulation-produced analgesia (SPA). Naloxone (2 mg/kg) exerted a partially antagonistic effect in relation to SPA in saline-treated and failed to abolish SPA in morphine-treated rats. It is concluded that the opiate component of the antinociceptive system is of importance for the tolerance development to morphine-like drugs.
在大鼠中确定了对伤害性刺激的复杂情绪反应成分以及导水管周围灰质（PAG）电刺激的抗伤害作用。动物用盐酸吗啡或生理盐水处理10天。亚慢性剂量（每天50mg/kg）期间吗啡的镇痛作用逐渐降低。刺激产生的镇痛（SPA）也是如此。纳洛酮（2mg/kg）对生理盐水处理的大鼠的SPA有部分拮抗作用，而对吗啡处理的大鼠未能消除SPA。结论是，抗伤害系统的阿片成分对于对吗啡样药物耐受性的发展很重要。
