γ-氨基丁酸（GABA）在乙醇和乙醛自我给药调节中的作用。

The role of gamma-aminobutyric acid (GABA) in the regulation of ethanol and acetaldehyde self-administration.

作者信息

Smith B R, Amit Z

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):759-63. doi: 10.1016/0278-5846(85)90056-9.

Abstract

Laboratory rats were presented with ethanol and water in a free-choice paradigm to determine each animal's preference for ethanol. Following a three week ethanol free period, it was observed that the duration of gamma-butyrolactone induced loss of righting reflex was negatively correlated to voluntary ethanol intake. It was also observed that the rate of intracerebroventricular self-administration of acetaldehyde was positively correlated with the latency to gamma-butyrolactone induced loss of righting reflex. These findings indicate that high ethanol drinking rats and high acetaldehyde self-administrating rats are less sensitive to the sedative action of gamma-butyrolactone.

摘要

在自由选择模式下给实验大鼠提供乙醇和水，以确定每只动物对乙醇的偏好。在三周无乙醇期后，观察到γ-丁内酯诱导的翻正反射丧失持续时间与自愿乙醇摄入量呈负相关。还观察到乙醛脑室内自我给药速率与γ-丁内酯诱导的翻正反射丧失潜伏期呈正相关。这些发现表明，高乙醇饮用大鼠和高乙醛自我给药大鼠对γ-丁内酯的镇静作用较不敏感。