Amit Z, Smith B R
Alcohol. 1985 Mar-Apr;2(2):367-70. doi: 10.1016/0741-8329(85)90077-1.
The suggestion that acetaldehyde may be endowed with positive reinforcing properties and may in fact mediate some of the psychopharmacological actions of ethanol has been examined by us and other investigators using a variety of paradigms. We first reported that non-dependent animals would self-administer acetaldehyde through an intra-cerebroventricular route. In addition, we have demonstrated that central infusion induced a conditioned place preference. We have also shown that an animal's propensity to self-administer acetaldehyde directly into the brain was related to its subsequent voluntary intake of ethanol. Lastly, we have reported that inhibition of acetaldehyde metabolism resulted in an enhancement of alcohol-induced euphoria in man. The data collected to date from four different paradigms strongly support the notion that acetaldehyde is endowed with positive reinforcing properties which may play a critical role in the mediation of ethanol euphoria.
乙醛可能具有正向强化特性，并且实际上可能介导乙醇的一些精神药理学作用，这一观点已由我们和其他研究人员使用多种范式进行了研究。我们首先报道，非依赖性动物会通过脑室内途径自我给药乙醛。此外，我们已经证明，中枢注射会诱导条件性位置偏好。我们还表明，动物将乙醛直接注射到大脑中的自我给药倾向与其随后自愿摄入乙醇有关。最后，我们报道，抑制乙醛代谢会增强人饮酒引起的欣快感。迄今为止，从四种不同范式收集的数据有力地支持了这一观点，即乙醛具有正向强化特性，这可能在介导乙醇欣快感中起关键作用。
