Chen Juejing, Zhao Yu, Lin Jianhang, Chen Quan, Guo Shaolei, Wan Pengxia
Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Department of Ophthalmology, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 510000, China.
Graefes Arch Clin Exp Ophthalmol. 2025 Sep 2. doi: 10.1007/s00417-025-06940-4.
To assess the condition of the ocular surface and electrophysiology in patients diagnosed with acoustic neuroma.
For this prospective case-control observational study, twenty-nine patients diagnosed with acoustic neuroma and eleven healthy individuals were included. All participants underwent a comprehensive ophthalmic assessment, including assessment of corneal sensitivity, morphologic examination of cornea nerves using in vivo confocal microscopy (IVCM), and electrophysiology evaluation.
In a cohort of 29 patients diagnosed with acoustic neuroma, 48.3% (n = 14) were male, with an average age of 49.10 ± 11.82 years. Conversely, within the group of 11 healthy participants, 54.5% (n = 6) were male, with an average age of 44.64 ± 8.14 years. The ST I and TFBUT exhibited decreased values in the ipsilateral eyes of patients with acoustic neuroma compared to the contralateral eyes (ST I: 8.25 [1.00, 30.00] vs. 10.35 [1.00, 30.00], P = 0.011; TFBUT: 4.70 [2.00, 15.00] vs. 6.35 [2.00, 15.00], P = 0.029). Furthermore, the ST values of acoustic neuroma negatively correlated with Hannover classification (β: -9.14 [-18.09, -0.18], P = 0.046). In terms of blink reflex electrophysiology, the latency of R1 and R2 waves on the ipsilateral side was prolonged compared to the contralateral sides (P < 0.05).
This study sheds light on the ocular manifestations of acoustic neuroma with a significant reduction in ST I values and TFBUT. This can be attributed to a decrease in the density of central corneal nerve and a change in blink reflex electrophysiology with a prolonged latency of R1 & R2 waves on the ipsilateral side.
评估诊断为听神经瘤患者的眼表状况和电生理情况。
在这项前瞻性病例对照观察性研究中，纳入了29例诊断为听神经瘤的患者和11名健康个体。所有参与者均接受了全面的眼科评估，包括角膜敏感性评估、使用活体共聚焦显微镜（IVCM）对角膜神经进行形态学检查以及电生理评估。
在29例诊断为听神经瘤的患者队列中，48.3%（n = 14）为男性，平均年龄为49.10±11.82岁。相反，在11名健康参与者组中，54.5%（n = 6）为男性，平均年龄为44.64±8.14岁。与对侧眼相比，听神经瘤患者患侧眼的ST I和TFBUT值降低（ST I：8.25 [1.00, 30.00] 对 10.35 [1.00, 30.00]，P = 0.011；TFBUT：4.70 [2.00, 15.00] 对 6.35 [2.00, 15.00]，P = 0.029）。此外，听神经瘤的ST值与汉诺威分类呈负相关（β：-9.14 [-18.09, -0.1'8]，P = 0.046）。在眨眼反射电生理方面，患侧R1和R2波的潜伏期比健侧延长（P < 0.05）。
本研究揭示了听神经瘤的眼部表现，ST I值和TFBUT显著降低。这可归因于中央角膜神经密度降低以及眨眼反射电生理变化，患侧R1和R2波潜伏期延长。
