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[线状视野共聚焦光学相干断层扫描在角质形成细胞癌及基底细胞癌切缘勾画中的应用]

[Line-field confocal optical coherence tomography in keratinocyte cancer and margin delineation in basal cell carcinoma].

作者信息

Mozaffari Marco, Fünfer Kristina, Welzel Julia, Schuh Sandra

机构信息

Klinik für Dermatologie und Allergologie, Universitätsklinikum Augsburg Medizincampus Süd, Sauerbruchstr. 6, 86179, Augsburg, Deutschland.

出版信息

Dermatologie (Heidelb). 2025 Sep 2. doi: 10.1007/s00105-025-05563-4.

Abstract

BACKGROUND

The number of patients with keratinocyte tumors is steadily increasing. In addition, personnel and procedural costs for surgical treatment are also rising.

OBJECTIVES

How suitable are modern, noninvasive dermatological imaging devices for improving the efficiency of tumor diagnostics and therapy in keratinocyte skin cancer, thereby enhancing treatment outcomes?

MATERIALS AND METHODS

Description of the process using a patient pathway and case studies, with discussion of existing literature and future perspectives.

RESULTS AND DISCUSSION

Modern noninvasive imaging techniques such as line-field confocal optical coherence tomography (LC-OCT) offer promising approaches in the surgical treatment of keratinocyte skin cancer, enabling high-resolution real-time tumor diagnostics. Early studies show that LC-OCT can be used both for early diagnosis without biopsy and for preoperative margin delineation of basal cell carcinomas. These techniques allow for efficiency-enhancing concepts in modern tumor therapy. However, clinical data on the practicability of these methods are currently lacking, highlighting the urgent need for validated studies for critical evaluation.

CONCLUSION

Noninvasive imaging can increase the efficiency of diagnosis and treatment of keratinocyte tumors through early and rapid diagnosis as well as artificial intelligence-assisted surgical planning.

摘要

背景

角质形成细胞肿瘤患者的数量在稳步增加。此外,手术治疗的人员和程序成本也在上升。

目的

现代非侵入性皮肤病学成像设备对于提高角质形成细胞皮肤癌的肿瘤诊断和治疗效率、从而改善治疗效果有多合适?

材料与方法

使用患者诊疗路径和案例研究描述过程,并讨论现有文献和未来前景。

结果与讨论

现代非侵入性成像技术,如线场共聚焦光学相干断层扫描(LC-OCT),在角质形成细胞皮肤癌的手术治疗中提供了有前景的方法,能够实现高分辨率实时肿瘤诊断。早期研究表明,LC-OCT既可以用于无需活检的早期诊断,也可以用于基底细胞癌的术前切缘划定。这些技术为现代肿瘤治疗中的效率提升理念提供了支持。然而,目前缺乏关于这些方法实用性的临床数据,这凸显了开展经过验证的研究以进行关键评估的迫切需求。

结论

非侵入性成像可以通过早期快速诊断以及人工智能辅助手术规划来提高角质形成细胞肿瘤的诊断和治疗效率。

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