Öztürk Yusuf, Atalay Dumlu Fadime, Aydın Berktaş Özlem
Faculty of Vocational School of Technical Sciences, Department of Hotel Restaurant and Catering Services, Ardahan, 75002, Turkey.
Faculty of Medicine, Department of Medical Biochemistry, Kafkas University, Kars, 36100, Turkey.
Plant Foods Hum Nutr. 2025 Sep 2;80(3):152. doi: 10.1007/s11130-025-01398-5.
This study evaluates the antioxidant and gastroprotective properties of hazelnut extracts in a rat model of indomethacin-induced gastric ulcers. The investigation focused on the potential therapeutic effects of different hazelnut extracts, specifically the methanol extract of Trabzon hazelnut, which exhibited the highest antioxidant activity (86.0% inhibition of lipid peroxidation) and phenolic content (significantly higher gallic acid equivalents). The extracts demonstrated significant gastroprotective effects by reducing ulcerated areas in rat gastric tissues induced by indomethacin, with the methanol extract of Trabzon hazelnut showing a 90.6% reduction in ulcer index at a dose of 100 mg/kg. Additionally, the extracts enhanced the antioxidant defence system by increasing catalase activity to 19.02 mmol/min/mg tissue, reducing lipid peroxidation levels to 52.67 nmol/g tissue, and restoring glutathione levels to 2.10 nmol/g tissue. These findings underscore the potential of hazelnut extracts as natural antioxidants and gastroprotective agents, highlighting their promise in mitigating oxidative stress and preventing chronic diseases. This analysis of multiple biochemical parameters, with a focus on both antioxidant and gastroprotective effects, provides a foundation for future research. Further research is recommended to explore the mechanisms underlying these effects, conduct clinical trials, and investigate potential food applications to expand the understanding of the antioxidant and gastroprotective properties of hazelnuts.
本研究在吲哚美辛诱导的大鼠胃溃疡模型中评估了榛子提取物的抗氧化和胃保护特性。该研究聚焦于不同榛子提取物的潜在治疗效果，特别是特拉布宗榛子的甲醇提取物，其表现出最高的抗氧化活性（脂质过氧化抑制率达86.0%）和酚类含量（没食子酸当量显著更高）。提取物通过减少吲哚美辛诱导的大鼠胃组织溃疡面积显示出显著的胃保护作用，特拉布宗榛子甲醇提取物在剂量为100 mg/kg时溃疡指数降低了90.6%。此外，提取物通过将过氧化氢酶活性提高到19.02 mmol/min/mg组织、将脂质过氧化水平降低到52.67 nmol/g组织以及将谷胱甘肽水平恢复到2.10 nmol/g组织，增强了抗氧化防御系统。这些发现强调了榛子提取物作为天然抗氧化剂和胃保护剂的潜力，突出了它们在减轻氧化应激和预防慢性疾病方面的前景。这种对多个生化参数的分析，重点关注抗氧化和胃保护作用，为未来的研究奠定了基础。建议进一步开展研究以探索这些作用的潜在机制、进行临床试验并研究潜在的食品应用，以加深对榛子抗氧化和胃保护特性的理解。
