Soydan Menekse, Arabaci Gulnur, Utlu Necati, Halici Mesut Bünyami, Aktas Senocak Esra, Kiliçlioglu Metin
Institute of Natural Sciences, Sakarya University, Sakarya 54187, Türkiye.
Department of Chemistry, Faculty of Science, Sakarya University, Sakarya 54187, Türkiye.
Pharmaceuticals (Basel). 2024 Dec 24;18(1):7. doi: 10.3390/ph18010007.
The plant . is employed in both raw and cooked forms for the treatment of gastric diseases, as an expectorant, and for the treatment of warts and the enhancement of urine. A review of the scientific literature revealed no studies investigating the effect of (MN) water extract on gastric diseases. The objective of this study was to determine the effect of a water extract of the MN plant on indomethacin-induced gastric ulcer in rats, using a series of biochemical (SOD, CAT, GSH and MDA levels) and histopathological parameters. 60 male Sprague Dawley rats were utilized for the purposes of evaluating the acute toxicity and gastric ulcer models, with a total of 36 rats employed for these experiments (n = 6). The rats were divided into six groups: intact; indomethacin; famotidine; indomethacin and MN (100, 200, 400 mg/kg). The Gastric tissue examinations at biochemical, macroscopic and pathological levels showed that MN extracts effectively prevented indo-methacin-induced gastric mucosal damage. The 400 mg/kg dose exhibited the most effective antiulcer effect, with a 69% protective efficacy. This dose caused an increase in the SOD, CAT and GSH levels and a decrease in the MDA levels compared to the IND group. Furthermore, an LC-MS/MS analysis was conducted on the water extract of MN, resulting in the identification of 14 phenolic compounds. Biochemical analyses and histopathological examinations demonstrated that the water extract of MN exhibited a beneficial protective effect against gastric ulceration due to its high antioxidant content.
这种植物的生熟两种形态都被用于治疗胃部疾病、作为祛痰剂以及治疗疣和促进排尿。对科学文献的综述显示，没有研究调查（MN）水提取物对胃部疾病的影响。本研究的目的是使用一系列生化指标（超氧化物歧化酶、过氧化氢酶、谷胱甘肽和丙二醛水平）和组织病理学参数，确定MN植物水提取物对吲哚美辛诱导的大鼠胃溃疡的影响。60只雄性Sprague Dawley大鼠用于评估急性毒性和胃溃疡模型，这些实验共使用了36只大鼠（每组6只）。大鼠被分为六组：完整组；吲哚美辛组；法莫替丁组；吲哚美辛和MN组（100、200、400毫克/千克）。在生化、宏观和病理水平上对胃组织的检查表明，MN提取物有效地预防了吲哚美辛诱导的胃黏膜损伤。400毫克/千克剂量表现出最有效的抗溃疡作用，保护功效为69%。与吲哚美辛组相比，该剂量导致超氧化物歧化酶、过氧化氢酶和谷胱甘肽水平升高，丙二醛水平降低。此外，对MN的水提取物进行了液相色谱-串联质谱分析，鉴定出14种酚类化合物。生化分析和组织病理学检查表明，MN的水提取物因其高抗氧化剂含量而对胃溃疡表现出有益的保护作用。
