Kratzer Tyler B, Mazzitelli Natalia, Star Jessica, Dahut William L, Jemal Ahmedin, Siegel Rebecca L
Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
CA Cancer J Clin. 2025 Sep 2. doi: 10.3322/caac.70028.
Prostate cancer is the most common cancer among men in the United States, and the incidence of advanced disease is increasing rapidly. This article provides an overview of prostate cancer occurrence using population-based incidence and mortality data from the National Cancer Institute and the Centers for Disease Control and Prevention. Prostate cancer incidence trends have reversed from a decline of 6.4% per year during 2007 through 2014 to an increase of 3.0% annually during 2014 through 2021. The increasing trend is confined to distant-stage disease in men younger than 55 years and to regional/distant-stage disease in men aged 55-69 years but includes early stage disease in men aged 70 years and older. Over the past decade of data, distant-stage disease has increased by 2.6% annually in men younger than 55 years, 6.0% annually in men aged 55-69 years, and 6.2% annually in men aged 70 years and older. American Indian/Alaska Native, Asian American/Pacific Islander, and Hispanic men are less likely than Black and White men to be diagnosed with localized disease (64%-67% vs. 71%-72%). Compared with White men, American Indian/Alaska Native men have 12% higher prostate cancer mortality despite 13% lower incidence, whereas Black men have double the prostate cancer mortality, with 67% higher incidence. In summary, continued increases in the diagnosis of advanced prostate cancer and persistent racial disparities underscore the need for redoubled efforts to optimize early detection while limiting overdiagnosis and to understand and address barriers to equitable outcomes.
前列腺癌是美国男性中最常见的癌症，晚期疾病的发病率正在迅速上升。本文利用美国国家癌症研究所和疾病控制与预防中心基于人群的发病率和死亡率数据，概述了前列腺癌的发病情况。前列腺癌的发病率趋势已从2007年至2014年每年下降6.4%逆转至2014年至2021年每年上升3.0%。这种上升趋势仅限于55岁以下男性的远处转移阶段疾病以及55 - 69岁男性的区域/远处转移阶段疾病，但包括70岁及以上男性的早期疾病。在过去十年的数据中，55岁以下男性的远处转移阶段疾病每年增加2.6%，55 - 69岁男性每年增加6.0%，70岁及以上男性每年增加6.2%。美国印第安人/阿拉斯加原住民、亚裔美国人/太平洋岛民和西班牙裔男性被诊断为局限性疾病的可能性低于黑人和白人男性（64% - 67%对71% - 72%）。与白人男性相比，美国印第安人/阿拉斯加原住民男性前列腺癌死亡率高出12%，尽管发病率低13%，而黑人男性前列腺癌死亡率是白人男性的两倍，发病率高出67%。总之，晚期前列腺癌诊断的持续增加和持续存在的种族差异凸显了加倍努力优化早期检测同时限制过度诊断以及理解和解决公平结果障碍的必要性。
