HWP1 Gene Sequence Diversity and Antifungal Susceptibility Patterns in Colombian Vulvovaginal Isolates of the Species Complex.

complex species are the main cause of candidiasis. The purpose of this study was to report the prevalence and genetic diversity of complex using hyphal wall protein 1 (HWP1) gene size polymorphism, as well as the susceptibility patterns to fluconazole and voriconazole. A total of 170 yeast isolates were obtained from vulvovaginal samples, and phenotypic and proteomic identification was performed. Most clinical isolates were complex ( = 153) followed by ( = 13), complex ( = 2), and ( = 2). Among complexes, all isolates were and 2.61% and 4.58% were resistant to fluconazole and voriconazole, respectively. The presence of different alleles was confirmed, heterozygosity was more common than homozygosity (71.03% vs. 28.97%), and some isolates showed a homozygosis pattern not previously described. Despite these genetic diversities, no specific genotype was linked to azole resistance.