不可切除或转移性肾上腺皮质癌的系统治疗前沿：利用新型治疗方法
Frontiers in Systemic Therapy for Unresectable or Metastatic Adrenocortical Carcinoma: Harnessing Novel Therapeutic Approaches.
作者信息
Singer Adam E, Kathuria-Prakash Nikhita, Shabsovich David, Garcia Lizette, Damron Leland, Pantuck Allan J, Drakaki Alexandra
机构信息
Division of Hematology/Oncology, Department of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
出版信息
Clin Med Insights Oncol. 2025 Aug 29;19:11795549251364042. doi: 10.1177/11795549251364042. eCollection 2025.
Adrenocortical carcinoma is a rare, aggressive endocrine malignancy with limited effective systemic therapy options and an overall poor prognosis for unresectable or metastatic disease. Chemotherapy and mitotane are the traditional systemic therapies of choice. More recently, as drug development in oncology has shifted away from chemotherapy, a host of therapeutic approaches targeting novel mechanisms of action has been studied in adrenocortical carcinoma. This review summarizes all nonchemotherapeutic approaches that have been and/or are currently being tested in clinical trials for the treatment of unresectable or metastatic adrenocortical carcinoma.
肾上腺皮质癌是一种罕见的侵袭性内分泌恶性肿瘤，有效的全身治疗选择有限，对于不可切除或转移性疾病总体预后较差。化疗和米托坦是传统的首选全身治疗方法。最近，随着肿瘤学药物研发从化疗转向，一系列针对新作用机制的治疗方法已在肾上腺皮质癌中进行了研究。本综述总结了所有已在和/或正在针对不可切除或转移性肾上腺皮质癌进行临床试验测试的非化疗方法。
Zotero 插件