Antonietti Michael, Schwartz Stephen G, Aguero Lazaro, Flynn Harry W
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
J Vitreoretin Dis. 2025 Aug 28:24741264251364011. doi: 10.1177/24741264251364011.
To describe a case series of patients who experienced hemorrhagic complications following intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. In a small case series of 3 patients with retinal disorders, imaging with ultrasound biomicroscopy (UBM) was performed within 1 day following anti-VEGF injection. The first patient had a mild vitreous hemorrhage, and UBM demonstrated a suspected needle track through the pars plana; the hemorrhage cleared spontaneously. The second patient had a dense vitreous hemorrhage as well as hyphema, and UBM demonstrated a suspected needle track through the pars plicata; the hemorrhage did not clear and the patient was subsequently treated elsewhere with pars plana vitrectomy. The third patient had a subconjunctival hemorrhage but no vitreous hemorrhage, and UBM demonstrated no definite evidence of a needle track. In some patients with vitreous hemorrhage following anti-VEGF injection, a suspected needle track may be imaged with UBM within 1 day following injection.
描述一系列在玻璃体内注射抗血管内皮生长因子（抗VEGF）后出现出血并发症的患者情况。在一个由3例视网膜疾病患者组成的小病例系列中，于抗VEGF注射后1天内进行了超声生物显微镜（UBM）成像检查。首例患者发生轻度玻璃体积血，UBM显示有一条疑似经睫状体扁平部的针道；出血自行吸收。第二例患者发生浓密的玻璃体积血以及前房积血，UBM显示有一条疑似经睫状襞的针道；出血未吸收，该患者随后转至其他地方接受了睫状体扁平部玻璃体切除术治疗。第三例患者发生结膜下出血但无玻璃体积血，UBM未显示明确的针道证据。在一些抗VEGF注射后发生玻璃体积血的患者中，注射后1天内用UBM可能会成像出疑似针道。
