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抗血管内皮生长因子药物玻璃体内注射相关的不良反应和并发症：文献复习。

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature.

机构信息

Department of Ophthalmology, Eye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Eye (Lond). 2013 Jul;27(7):787-94. doi: 10.1038/eye.2013.107. Epub 2013 May 31.

DOI:10.1038/eye.2013.107
PMID:23722722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3709385/
Abstract

Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is increasingly used for the treatment of a wide variety of retinal diseases, including age-related macular degeneration, diabetic retinopathy and retinal vascular occlusions, and retinopathy of prematurity. Despite encouraging results in halting the disease and improving the vision, intravitreal injection of anti-VEGF agents may be associated with systemic adverse events and devastating ocular complications. In this review, we provide an overview of safety data for intravitreal injection of common anti-VEGF agents.

摘要

玻璃体内注射抗血管内皮生长因子 (VEGF) 药物越来越多地用于治疗各种视网膜疾病，包括年龄相关性黄斑变性、糖尿病性视网膜病变和视网膜血管阻塞以及早产儿视网膜病变。尽管在阻止疾病和改善视力方面取得了令人鼓舞的结果，但玻璃体内注射抗 VEGF 药物可能与全身不良事件和严重的眼部并发症有关。在这篇综述中，我们提供了常见抗 VEGF 药物玻璃体内注射的安全性数据概述。

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本文引用的文献

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Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center.单中心玻璃体腔注射贝伐单抗后急性眼内炎的发生率。
Retina. 2013 May;33(5):971-4. doi: 10.1097/IAE.0b013e31826f0675.
2
A safety review and meta-analyses of bevacizumab and ranibizumab: off-label versus goldstandard.贝伐单抗和雷珠单抗的安全性回顾和荟萃分析：超适应证与金标准。
PLoS One. 2012;7(8):e42701. doi: 10.1371/journal.pone.0042701. Epub 2012 Aug 3.
3
Delayed onset atypical vitreoretinal traction band formation after an intravitreal injection of bevacizumab in stage 3 retinopathy of prematurity.早产儿视网膜病变 3 期玻璃体内注射贝伐单抗后迟发性非典型玻璃体视网膜牵引带形成。
Eye (Lond). 2012 Jul;26(7):903-9; quiz 910. doi: 10.1038/eye.2012.111. Epub 2012 Jun 15.
4
Successful management of choroidal metastasis with intravitreal ranibizumab injections.玻璃体内注射雷珠单抗成功治疗脉络膜转移瘤。
Ophthalmic Surg Lasers Imaging. 2012 May 24;43 Online:e47-51. doi: 10.3928/15428877-20120517-03.
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Reactivation of retinopathy of prematurity after bevacizumab injection.注射贝伐单抗后早产儿视网膜病变复发。
Arch Ophthalmol. 2012 Aug;130(8):1000-6. doi: 10.1001/archophthalmol.2012.592.
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Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection.眼内注射后反复使用局部抗生素导致结膜菌群耐药模式的变化。
Ophthalmology. 2012 Jul;119(7):1420-4. doi: 10.1016/j.ophtha.2012.01.016. Epub 2012 Mar 13.
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Reducing oral flora contamination of intravitreal injections with face mask or silence.使用口罩或保持安静减少玻璃体腔内注射时的口腔菌群污染。
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