纵隔隐球菌瘤作为合并重症肌无力的HIV阴性孕妇播散性隐球菌病的一部分：尸检病例报告

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report.

作者信息

Samy Bianca Ponnamma, Thobakgale Nosipho Maria, Khaba Moshawa Calvin

机构信息

Department of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, South Africa.

出版信息

Med Mycol Case Rep. 2025 Aug 20;49:100726. doi: 10.1016/j.mmcr.2025.100726. eCollection 2025 Sep.

DOI:10.1016/j.mmcr.2025.100726

PMID:40893460

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12397806/

Abstract

Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

摘要

隐球菌病是一种常见于免疫功能低下个体的真菌感染，但也可影响免疫功能正常的个体。一名患有重症肌无力、HIV阴性的孕妇在被诊断为肺结核后死亡。尸检发现纵隔肿块和器官受累，提示播散性隐球菌感染。该病例强调了即使在没有HIV/AIDS的免疫抑制个体中，对隐球菌感染保持高度怀疑指数的重要性。通过检测血清隐球菌抗原可实现早期诊断。