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从喜马拉雅地区分离出的WGPSB - 2的基因组特征及致病机制

Genomic characterization and pathogenic mechanisms of WGPSB-2 isolated from the Himalayas.

作者信息

Subanna A R N S, Singh Ashish Kumar, Paschapur Amit U, Karki Nutan, Bhat Sunaullah, J Stanley, Mishra K K, Kant Lakshmi

机构信息

ICAR-Indian Institute of Oil Palm Research, Andhra Pradesh, 534475, India.

ICAR-Vivekananda Parvatiya Krishi Anusandhan Sansthan, Almora, 263601, Uttarakhand, India.

出版信息

New Microbes New Infect. 2025 Aug 6;67:101616. doi: 10.1016/j.nmni.2025.101616. eCollection 2025 Oct.

DOI:10.1016/j.nmni.2025.101616
PMID:40893478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12391255/
Abstract

The utilization of microbial agents for the management of white grub has been a long-standing practice in biocontrol. In a previous study, we isolated entomopathogenic bacteria WGPSB-2 from the Himalayan region. To gain insights into the genetic characteristics and potential mechanisms underlying the pathogenicity of WGPSB-2, we performed genomic analysis of WGPSB-2. The genome has 9 contigs with a total length of 4.98 megabases, GC content of 35 %, 4506 protein-coding genes, 55 tRNA, and 30 rRNA. In the genome of , a total of 37 genes predicted to encode peptide synthetases. Among these, five core biosynthetic gene clusters including , , , , and have been predicted. The results revealed that the WGPSB-2 strain possesses several genetic attributes associated with insect pathogenicity, including the presence of toxin-encoding genes and genes involved in entomopathogenicity. Comparative analysis with other entomopathogenic bacterial strain revealed high degree of genetic similarity, suggesting that the WGPSB-2 is closely related to other insect pathogenic strains. The findings may inform the development of novel strategies for pest management and provide a foundation for future studies on the genetic diversity and evolution of insect pathogenicity in .

摘要

利用微生物制剂防治蛴螬在生物防治中由来已久。在之前的一项研究中，我们从喜马拉雅地区分离出了昆虫病原细菌WGPSB - 2。为深入了解WGPSB - 2的遗传特征及其致病的潜在机制，我们对WGPSB - 2进行了基因组分析。该基因组有9个重叠群，总长度为498万个碱基对，GC含量为35%，有4506个蛋白质编码基因、55个tRNA和30个rRNA。在该基因组中，共有37个基因被预测编码肽合成酶。其中，已预测出包括、、、和在内的5个核心生物合成基因簇。结果表明，WGPSB - 2菌株具有几个与昆虫致病性相关的遗传特性，包括毒素编码基因和参与昆虫致病性的基因的存在。与其他昆虫病原细菌菌株的比较分析显示出高度的遗传相似性，这表明WGPSB - 2与其他昆虫致病菌株密切相关。这些发现可能为害虫管理新策略的开发提供信息，并为未来关于昆虫致病性的遗传多样性和进化的研究奠定基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/e3d21ed8071b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/0565aff2e7e2/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/a817619cc70e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/c2c106bdd452/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/9f42e0899570/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/9ebcbf4f1646/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/7cc5a7dc0742/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/55bca8d445a4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/c658f4fc25bd/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/e3d21ed8071b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/0565aff2e7e2/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/a817619cc70e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/c2c106bdd452/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/9f42e0899570/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/9ebcbf4f1646/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/7cc5a7dc0742/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/55bca8d445a4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/c658f4fc25bd/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/12391255/e3d21ed8071b/gr8.jpg

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