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Quest for an accurate and reproducible prognostic biomarker of severe acute pancreatitis: have we finally found it?

作者信息

Lee Peter J, Gorelick Fred S, Papachristou Georgios I

机构信息

Division of Gastroenterology and Hepatology, Ohio State University Wexner Medical Center, Columbus, OH, USA.

Veterans Affairs Health Care System, Yale University, New Haven, CT, USA.

出版信息

Hepatobiliary Surg Nutr. 2025 Aug 1;14(4):639-642. doi: 10.21037/hbsn-2025-159. Epub 2025 Jul 25.

DOI:10.21037/hbsn-2025-159
PMID:40893762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393122/
Abstract
摘要

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本文引用的文献

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Serum Exosomal miR-216a Contributes to Acute Pancreatitis-Associated Acute Lung Injury by Enhancing Endothelial Cell Vascular Permeability Through Downregulating LAMC1.血清外泌体miR-216a通过下调LAMC1增强内皮细胞血管通透性，从而导致急性胰腺炎相关性急性肺损伤。
Pancreas. 2025 Jul 1;54(6):e537-e546. doi: 10.1097/MPA.0000000000002467.
2
A Novel Serum Exosomal MicroRNA Signature in the Early Prediction of Persistent Organ Failure in Patients With Acute Pancreatitis.一种用于急性胰腺炎患者持续性器官衰竭早期预测的新型血清外泌体微小RNA特征
Ann Surg. 2025 Jul 1;282(1):93-99. doi: 10.1097/SLA.0000000000006229. Epub 2024 Feb 7.
3
A beginner's guide to study extracellular vesicles in human blood plasma and serum.
人类血浆和血清中外泌体研究入门指南。
J Extracell Vesicles. 2024 Jan;13(1):e12400. doi: 10.1002/jev2.12400.
4
Clinical usefulness of scoring systems to predict severe acute pancreatitis: A systematic review and meta-analysis with pre and post-test probability assessment.评分系统对预测重症急性胰腺炎的临床实用性：系统评价和荟萃分析，包括前后测试概率评估。
United European Gastroenterol J. 2023 Nov;11(9):825-836. doi: 10.1002/ueg2.12464. Epub 2023 Sep 27.
5
Targeting IL-6 trans-signalling: past, present and future prospects.靶向 IL-6 转导信号：过去、现在和未来的前景。
Nat Rev Immunol. 2023 Oct;23(10):666-681. doi: 10.1038/s41577-023-00856-y. Epub 2023 Apr 17.
6
Differential expression of plasma exosomal microRNA in severe acute pancreatitis.血浆外泌体微小RNA在重症急性胰腺炎中的差异表达
Front Pharmacol. 2022 Sep 28;13:980930. doi: 10.3389/fphar.2022.980930. eCollection 2022.
7
Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models.吡非尼酮增加了白细胞介素-10，改善了多种临床相关的小鼠模型中的急性胰腺炎。
JCI Insight. 2022 Jan 25;7(2):e141108. doi: 10.1172/jci.insight.141108.
8
Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor.奥昔拉治疗伴有全身炎症反应综合征的急性胰腺炎患者：钙释放激活钙通道抑制剂的临床开发。
Pancreas. 2021 Apr 1;50(4):537-543. doi: 10.1097/MPA.0000000000001793.
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Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected.在持续性器官衰竭的急性胰腺炎中，死亡率取决于受影响的器官系统的数量、类型和顺序。
United European Gastroenterol J. 2021 Mar;9(2):139-149. doi: 10.1002/ueg2.12057.
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Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1;319(5):G573-G583. doi: 10.1152/ajpgi.00285.2020. Epub 2020 Sep 2.