Jin Zheng, Zhu Zhenhua, Jing Xiaopeng, Zeng Ji, Yan Dongmei
Department of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan City, Hubei Province, China.
Department of Joint Surgery, Wuhan Fourth Hospital, Wuhan City, Hubei Province, China.
Biochem Biophys Rep. 2025 Aug 19;43:102212. doi: 10.1016/j.bbrep.2025.102212. eCollection 2025 Sep.
Allergic asthma, known for its airway hyperresponsiveness and remodeling, is a prevalent chronic respiratory disease. Recent investigations have emphasized the crucial role of ubiquitination, a post-translational modification, in the pathogenesis of allergic asthma. Ubiquitination involves the addition of ubiquitin molecules to substrates, caused their degradation or alteration in activity. Ubiquitination affects various aspects of immune cell function, such as activation of Th2 cells, B cells, and antigen-presenting cells, which are vital to allergic asthma. In this review, we explore the role of ubiquitination in modulating immune responses during allergic asthma. We discuss the interplay between ubiquitin ligases, their substrates, and the impact on immune cell function, including Th2 differentiation and Th2 cytokines production. Our study also considers the potential therapeutic outcomes of targeting ubiquitination in asthma management. By understanding the complex interplay between ubiquitination, immune cells and immune responses, we can identify new molecules for treating allergic asthma, potentially leading to more effective therapies that modulate immune responses and ameliorate disease symptoms.
过敏性哮喘以气道高反应性和重塑为特征，是一种常见的慢性呼吸道疾病。最近的研究强调了泛素化（一种翻译后修饰）在过敏性哮喘发病机制中的关键作用。泛素化涉及将泛素分子添加到底物上，导致其降解或活性改变。泛素化影响免疫细胞功能的各个方面，如Th2细胞、B细胞和抗原呈递细胞的激活，这些对过敏性哮喘至关重要。在本综述中，我们探讨了泛素化在调节过敏性哮喘免疫反应中的作用。我们讨论了泛素连接酶、其底物之间的相互作用以及对免疫细胞功能的影响，包括Th2分化和Th2细胞因子的产生。我们的研究还考虑了靶向泛素化在哮喘管理中的潜在治疗效果。通过了解泛素化、免疫细胞和免疫反应之间的复杂相互作用，我们可以识别出治疗过敏性哮喘的新分子，有可能带来更有效的调节免疫反应和改善疾病症状的疗法。
