打断 K48 链：连接泛素超越蛋白质降解。
Breaking the K48-chain: linking ubiquitin beyond protein degradation.
机构信息
Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Nat Struct Mol Biol. 2024 Feb;31(2):216-218. doi: 10.1038/s41594-024-01221-w. Epub 2024 Feb 16.
Abstract
The discovery of ubiquitin conjugation to lysines and the role of K48-linked polyubiquitin in targeting substrates for proteasomal degradation was followed by revelation of non-degradative roles of ubiquitination and, more recently, of non-canonical covalent ubiquitin linkages. Here we summarize findings of the ever-expanding array of ubiquitin signals and their biological roles.
摘要
泛素与赖氨酸的连接以及 K48 连接的多泛素在靶向蛋白酶体降解底物中的作用的发现，随后揭示了泛素化的非降解作用，以及最近揭示了非典型的共价泛素连接。在这里，我们总结了不断扩展的泛素信号及其生物学作用的发现。
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