Hassan Shafie Abdulkadir, Mohamed Mowlid Abdikarin, Salad Zeynab Abdi, Mohamed Nimo Dahir, Ahmed Fardowsa Abdulahi, Dirie Farhan Abdiaziz, Abdulle Mohamed Khalif, Omar Abdifetah Ibrahim, Ahmed Nur Rashid
Department of Medical Laboratory Sciences, Faculty of Medicine and Health Sciences, Jamhuriya University of Science and Technology, Mogadishu, Somalia.
Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Jamhuriya University of Science and Technology, Mogadishu, Somalia.
IJID Reg. 2025 Jul 30;16:100717. doi: 10.1016/j.ijregi.2025.100717. eCollection 2025 Sep.
Methicillin-resistant (MRSA) causes severe infections with high mortality rates and health care costs. This study aimed to evaluate the prevalence of MRSA and its associated factors among patients with wound infections at Shaafi Hospital in Mogadishu, Somalia.
Wound swabs were collected from 418 patients with surgical wounds and cultured on Mannitol salt agar. was identified using conventional methods, and antimicrobial susceptibility was performed using the disk diffusion method. Data analysis was conducted using SPSS software, with results presented as frequencies and percentages. Chi-square tests and binary logistic regression were performed to identify associations between MRSA and independent variables.
was isolated in 116 (27.8%) patients, with 31 (26.7%) cases identified as MRSA. The prevalence of MRSA was higher among females (10, 27%) than males (21, 26.6%). The most frequent MRSA was observed in the 21-30 years age group (13, 24.5%). Patients with deep wounds had a significant association with MRSA (adjusted odds ratio [AOR]: 4.32, 95% confidence interval [CI]: 1.042-17.92, <0.044). Hospital stay of longer than 72 hours (AOR: 4.1, 95% CI: 1.22-13.80, <0.022) and history of antibiotic use (AOR: 1.12, 95% CI: 0.17-7.15, <0.018) were also found significant risk factors. Penicillin was 100% resistant to MRSA, followed by 58% to cotrimoxazole, 54.8% to gentamycin, and 51.6% to ciprofloxacin, whereas MRSA was 100% susceptible to vancomycin.
The prevalence of MRSA among inpatients with surgical wounds is considerable, with specific risk factors such as deep wounds, prolonged hospital stays, and previous antibiotic use significantly increasing the likelihood of MRSA infection. Antibiogram results indicated a significant resistance to frequently used antibiotics. This emphasizes the importance of implementing effective infection control measures and practicing antibiotic stewardship to manage MRSA in hospitals.
耐甲氧西林金黄色葡萄球菌（MRSA）可引发严重感染，死亡率高且医疗成本高昂。本研究旨在评估索马里摩加迪沙沙菲医院伤口感染患者中MRSA的流行情况及其相关因素。
从418例手术伤口患者中采集伤口拭子，接种于甘露醇盐琼脂培养基上进行培养。采用常规方法鉴定，并用纸片扩散法进行药敏试验。使用SPSS软件进行数据分析，结果以频率和百分比表示。进行卡方检验和二元逻辑回归分析以确定MRSA与自变量之间的关联。
在116例（27.8%）患者中分离出该菌，其中31例（26.7%）被鉴定为MRSA。女性（10例，27%）中MRSA的患病率高于男性（21例，26.6%）。在21 - 30岁年龄组中观察到的MRSA最为常见（13例，24.5%）。深部伤口患者与MRSA存在显著关联（调整优势比[AOR]：4.32，95%置信区间[CI]：1.042 - 17.92，P<0.044）。住院时间超过72小时（AOR：4.1，95%CI：1.22 - 13.80，P<0.022）和抗生素使用史（AOR：1.12，95%CI：0.17 - 7.15，P<0.018）也是显著的危险因素。青霉素对MRSA的耐药率为100%，其次是复方新诺明58%、庆大霉素54.8%、环丙沙星51.6%，而MRSA对万古霉素100%敏感。
手术伤口住院患者中MRSA的患病率相当高，深部伤口、住院时间延长和既往抗生素使用等特定危险因素显著增加了MRSA感染的可能性。药敏结果表明对常用抗生素存在显著耐药性。这强调了实施有效的感染控制措施和践行抗生素管理以控制医院内MRSA感染的重要性。
