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冠状动脉旁路移植术术后中风:约旦中风发病率及相关危险因素的十年研究

Postoperative stroke in CABG: a ten-year study of stroke incidence and contributing risk factors in Jordan.

作者信息

Hijazi Emad, Al-Zoubi Nabil, Aljarrah Qusai

机构信息

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

King Abdullah University Hospital, Irbid, Jordan.

出版信息

J Med Life. 2025 Jul;18(7):621-625. doi: 10.25122/jml-2024-0326.

DOI:10.25122/jml-2024-0326
PMID:40893817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12391899/
Abstract

Stroke is a serious complication that occurs in approximately 3% of patients undergoing elective coronary artery bypass grafting (CABG). Neurologic dysfunction is a well-researched challenge in cardiac surgery, particularly when cardiopulmonary bypass is used. This study aimed to determine the stroke rate following CABG in a Jordanian population, based on our experience at a low-volume cardiac center. We conducted an observational descriptive study involving 446 patients who underwent CABG between January 2011 and December 2021. Stroke occurred in five patients (1.12%). Among 208 female patients, four developed stroke (1.9%), three of whom had diabetes mellitus (75%), and two had a prior history of transient ischemic attacks (TIAs). In contrast, only one out of 238 male patients experienced a stroke (0.4%); this patient had diabetes but had no history of TIA. The incidence of stroke in female patients was four times higher than in men. These findings suggest that improving surgical techniques, particularly in low-resource or developing settings, may contribute to reducing the risk of postoperative stroke. Strategies such as minimizing aortic manipulation during CABG while utilizing cardiopulmonary bypass could be beneficial, especially in patients with known risk factors for cerebrovascular events.

摘要

中风是一种严重的并发症,约3%接受择期冠状动脉搭桥术(CABG)的患者会发生。神经功能障碍是心脏手术中一个经过充分研究的挑战,尤其是在使用体外循环时。本研究旨在根据我们在一个低容量心脏中心的经验,确定约旦人群中冠状动脉搭桥术后的中风发生率。我们进行了一项观察性描述性研究,纳入了2011年1月至2021年12月期间接受冠状动脉搭桥术的446例患者。有5例患者(1.12%)发生了中风。在208例女性患者中,有4例发生中风(1.9%),其中3例患有糖尿病(75%),2例有短暂性脑缺血发作(TIA)病史。相比之下,238例男性患者中只有1例发生中风(0.4%);该患者患有糖尿病,但无TIA病史。女性患者的中风发生率是男性的四倍。这些发现表明,改进手术技术,尤其是在资源匮乏或发展中地区,可能有助于降低术后中风的风险。在冠状动脉搭桥术期间利用体外循环时尽量减少主动脉操作等策略可能是有益的,特别是对于有已知脑血管事件危险因素的患者。

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Effect of smoking on the development of chronic obstructive pulmonary disease in young individuals: a nationwide cohort study.吸烟对年轻人慢性阻塞性肺疾病发生发展的影响:一项全国性队列研究。
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World J Cardiol. 2021 Aug 26;13(8):309-324. doi: 10.4330/wjc.v13.i8.309.
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Nonselective carotid artery ultrasound screening in patients undergoing coronary artery bypass grafting: Is it necessary?冠状动脉搭桥手术患者的非选择性颈动脉超声筛查:有必要吗?
J Thorac Cardiovasc Surg. 2016 Feb;151(2):402-8. doi: 10.1016/j.jtcvs.2015.09.108. Epub 2015 Oct 3.
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Predictors associated with stroke after coronary artery bypass grafting: a systematic review.冠状动脉搭桥术后与卒中相关的预测因素:一项系统综述
J Neurol Sci. 2015 Oct 15;357(1-2):1-7. doi: 10.1016/j.jns.2015.07.006. Epub 2015 Jul 4.
9
There is no benefit to universal carotid artery duplex screening before a major cardiac surgical procedure.在进行重大心脏外科手术前,进行普遍的颈动脉双功超声筛查并无益处。
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Trends in aortic clamp use during coronary artery bypass surgery: effect of aortic clamping strategies on neurologic outcomes.冠状动脉旁路移植术中主动脉夹的使用趋势:主动脉夹闭策略对神经系统转归的影响。
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