• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Symptoms and adverse events in controlled human infection models.

作者信息

Götz Karen, Luga Poleta, Rengel Jörg, Masur Mei, Juárez-Hernández Marcela, Bekeredjian-Ding Isabelle

机构信息

Division of Infectious Disease, Paul-Ehrlich-Institut, Langen, Germany.

Institute for Medical Microbiology and Hospital Hygiene and Regulatory Intelligence Team, Philipps-University Marburg, Marburg, Germany.

出版信息

Front Med (Lausanne). 2025 Aug 14;12:1578560. doi: 10.3389/fmed.2025.1578560. eCollection 2025.

DOI:10.3389/fmed.2025.1578560
PMID:40893872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12392999/
Abstract
摘要

相似文献

1
Symptoms and adverse events in controlled human infection models.人体感染对照模型中的症状和不良事件。
Front Med (Lausanne). 2025 Aug 14;12:1578560. doi: 10.3389/fmed.2025.1578560. eCollection 2025.
2
Exploring the participant experience in controlled human infection model (CHIM) trials: A modified grounded theory study.探索可控人类感染模型(CHIM)试验中的参与者体验:一项修正的扎根理论研究。
PLoS One. 2025 Aug 6;20(8):e0328378. doi: 10.1371/journal.pone.0328378. eCollection 2025.
3
Vaccines for preventing infections in adults with haematological malignancies.用于预防血液系统恶性肿瘤成人感染的疫苗。
Cochrane Database Syst Rev. 2025 May 21;5(5):CD015530. doi: 10.1002/14651858.CD015530.pub2.
4
Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.第四次人工感染控制模型(CHIM)会议,CHIM 监管问题,2023 年 5 月 24 日。
Biologicals. 2024 Feb;85:101745. doi: 10.1016/j.biologicals.2024.101745. Epub 2024 Feb 10.
5
Selecting candidate Neisseria gonorrhoeae strains for oropharyngeal gonorrhoea human challenge: a genomics-based analysis of clinical isolates.选择用于口咽淋病人体激发试验的淋病奈瑟菌候选菌株:基于基因组学的临床分离株分析
Lancet Microbe. 2025 Jul 10:101105. doi: 10.1016/j.lanmic.2025.101105.
6
Controlled Human Infection Studies Accelerate Vaccine Development.人体感染对照研究加速疫苗研发。
J Infect Dis. 2025 Jun 2;231(5):1112-1116. doi: 10.1093/infdis/jiaf053.
7
Bioethics of establishing a CHIM model for dengue vaccine development.建立登革热疫苗开发中中印尼卫生健康研究合作模式的生物伦理学。
Int J Infect Dis. 2019 Jul;84S:S74-S79. doi: 10.1016/j.ijid.2019.01.013. Epub 2019 Jan 11.
8
Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023.第四次人类感染控制模型(CHIM)会议-地方性流行国家的 CHIM,2023 年 5 月 22 日-23 日。
Biologicals. 2024 Feb;85:101747. doi: 10.1016/j.biologicals.2024.101747. Epub 2024 Feb 13.
9
A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?A 型咽炎的人体感染控制模型:选用哪种菌株及原因?
mSphere. 2019 Feb 13;4(1):e00647-18. doi: 10.1128/mSphere.00647-18.
10
Safety and immunogenicity of the Euvichol-S oral cholera vaccine for prevention of Vibrio cholerae O1 infection in Nepal: an observer-blind, active-controlled, randomised, non-inferiority, phase 3 trial.Euvichol-S 口服霍乱疫苗预防尼泊尔 O1 群霍乱弧菌感染的安全性和免疫原性:一项观察者盲法、活性对照、随机、非劣效性、3 期临床试验。
Lancet Glob Health. 2024 May;12(5):e826-e837. doi: 10.1016/S2214-109X(24)00059-7.

本文引用的文献

1
The First- and Second-Order Ethical Reasons Approach: The Case of Human Challenge Trials.一阶和二阶伦理理由方法:人体挑战试验案例。
Ethics Hum Res. 2024 Sep-Oct;46(5):26-36. doi: 10.1002/eahr.500223.
2
A feasibility study of controlled human infection with intradermal Bacillus Calmette-Guérin (BCG) injection: Pilot BCG controlled human infection model.皮内注射卡介苗(BCG)进行人体感染控制的可行性研究:卡介苗人体感染控制试验模型。
Wellcome Open Res. 2024 Jun 5;8:424. doi: 10.12688/wellcomeopenres.19811.2. eCollection 2023.
3
Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis.
沙蝇传播的皮肤利什曼病人体感染模型的安全性和反应原性。
Nat Med. 2024 Nov;30(11):3150-3162. doi: 10.1038/s41591-024-03146-9. Epub 2024 Aug 2.
4
Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study.在英国健康的血清阳性成年人中接种 SARS-CoV-2 的安全性、耐受性、病毒动力学和免疫保护相关性:一项单中心、开放性、1 期对照人体感染研究。
Lancet Microbe. 2024 Jul;5(7):655-668. doi: 10.1016/S2666-5247(24)00025-9. Epub 2024 May 1.
5
Ethical approval for controlled human infectious model clinical trial protocols - A workshop report.伦理审批在人体感染性疾病模型临床试验方案中的应用——研讨会报告。
Biologicals. 2024 Feb;85:101748. doi: 10.1016/j.biologicals.2024.101748. Epub 2024 Feb 12.
6
Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.第四次人工感染控制模型(CHIM)会议,CHIM 监管问题,2023 年 5 月 24 日。
Biologicals. 2024 Feb;85:101745. doi: 10.1016/j.biologicals.2024.101745. Epub 2024 Feb 10.
7
Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report.监管研讨会:挑战株开发和 GMP 生产——利益相关者会议报告。
Biologicals. 2024 Feb;85:101746. doi: 10.1016/j.biologicals.2024.101746. Epub 2024 Feb 3.
8
Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial.美国钩虫幼虫短期感染对荷兰健康志愿者的保护效力:一项单中心、安慰剂对照、随机、对照、1 期临床试验。
Lancet Microbe. 2023 Dec;4(12):e1024-e1034. doi: 10.1016/S2666-5247(23)00218-5.
9
TV005 dengue vaccine protects against dengue serotypes 2 and 3 in two controlled human infection studies.TV005 登革热疫苗在两项人体感染对照研究中可预防登革热血清型 2 和 3。
J Clin Invest. 2024 Feb 1;134(3):e173328. doi: 10.1172/JCI173328.
10
Adopting human factors in early phase and experimental medicine research: A nested pilot study observing controlled human infection with SARS-CoV-2.采用人因工程学于早期阶段和实验医学研究:嵌套式初步研究观察 SARS-CoV-2 的人体感染控制。
Br J Clin Pharmacol. 2024 Jul;90(7):1586-1599. doi: 10.1111/bcp.15949. Epub 2023 Nov 22.