Huang Shan-Shan, Yu Xiao-Shuang, Lin Tong, Xie Zhen-Ye, Mao Hai-Yan, Yang Zhou-Xin
Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Department of Otolaryngology, Jiangshan People's Hospital, Quzhou, China.
Front Med (Lausanne). 2025 Aug 5;12:1588835. doi: 10.3389/fmed.2025.1588835. eCollection 2025.
Cardiovascular health (CVH) profoundly impacts human health and quality of life. Increasing evidence suggests a close association between cardiovascular disease (CVD) and systemic immune-inflammatory levels. This study explores the potential correlation between Life's Essential 8 (LE8) scores and the systemic immune-inflammation index (SII), a novel immune-inflammatory index among US adults. This study provides evidence supporting the role of systemic inflammation reduction in promoting CVH.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2018, we investigated information from 21,403 adult participants. Participants were categorized into low CVH (0-49), moderate CVH (50-79), and high CVH (80-100) groups based on LE8 scores. We employed weighted linear regression analysis and subgroup analysis, along with restricted cubic spline curves (RCS) to explore the association between LE8 and SII and the dose-response relationship.
A significant negative correlation was found between higher LE8 scores and lower SII levels. Compared to the low CVH group, the β coefficients for SII in the CVH moderate and CVH high groups were -40.02 (95% CI: -58.99 to -21.05, < 0.001) and -77.62 (95% CI: -102.4 to -52.80, < 0.001), respectively. Additionally, both LE8 scores and health behaviors scores showed a significant linear negative correlation with SII. There was an inverted "U-shaped" non-linear relationship between health factors scores and SII, and the health factor score was 284.724, with a maximum SII threshold of 518.010 (1,000 cells/μl). The health factor score is positively associated with SII below 518.010 and negatively associated above this threshold. Subgroup analyses showed that the negative association was stable in most subgroups. The negative correlation was insignificant among those aged >65 and Mexican Americans.
LE8 showed a significant negative correlation with SII. The findings suggest that maintaining higher LE8 scores to some extent promotes CVH and helps alleviate systemic inflammation, potentially benefiting overall health.
心血管健康（CVH）对人类健康和生活质量有着深远影响。越来越多的证据表明心血管疾病（CVD）与全身免疫炎症水平之间存在密切关联。本研究探讨了美国成年人中生命必需8项（LE8）评分与全身免疫炎症指数（SII，一种新型免疫炎症指标）之间的潜在相关性。本研究为支持降低全身炎症在促进心血管健康中的作用提供了证据。
利用2007年至2018年美国国家健康与营养检查调查（NHANES）的数据，我们调查了21403名成年参与者的信息。根据LE8评分，参与者被分为低心血管健康组（0 - 49）、中等心血管健康组（50 - 79）和高心血管健康组（80 - 100）。我们采用加权线性回归分析和亚组分析，以及受限立方样条曲线（RCS）来探讨LE8与SII之间的关联以及剂量反应关系。
较高的LE8评分与较低的SII水平之间存在显著负相关。与低心血管健康组相比，中等心血管健康组和高心血管健康组中SII的β系数分别为 - 40.02（95%置信区间： - 58.99至 - 21.05，<0.001）和 - 77.62（95%置信区间： - 102.4至 - 52.80，<0.001）。此外，LE8评分和健康行为评分均与SII呈显著线性负相关。健康因素评分与SII之间存在倒“U”形非线性关系，健康因素评分为284.724，SII的最大阈值为518.010（1000个细胞/μl）。在518.010以下，健康因素评分与SII呈正相关，高于此阈值则呈负相关。亚组分析表明，这种负相关在大多数亚组中是稳定的。在65岁以上人群和墨西哥裔美国人中，这种负相关不显著。
LE8与SII呈显著负相关。研究结果表明，在一定程度上维持较高的LE8评分可促进心血管健康，并有助于减轻全身炎症，可能有益于整体健康。
