Li Zhe, Marion Danielle, Blair Jessica, Soliman Elsayed Z, Gladstone David, Kamel Hooman, Birnie David, Manuel Doug, Unverzagt Frederick W, Howard Virginia, Edwards Jodi D
University of Ottawa Heart Institute.
The University of Alabama at Birmingham.
Res Sq. 2025 Aug 19:rs.3.rs-6872566. doi: 10.21203/rs.3.rs-6872566/v1.
The study aims to investigate associations between markers of atrial cardiopathy and cognitive function trajectories in adults without prior AF.
The study included 4,486 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Markers of atrial cardiopathy included atrial premature complexes and N-Terminal pro-Brain Natriuretic Peptide (NT pro-BNP). Cognitive status was measured using the Six-Item Screener (SIS). Cognitive status trajectories were identified using latent class growth models.
Three unique cognitive trajectories over the 8-year follow-up were identified: 86.7% showed a normal and stable trajectory of SIS score, 7.6% showed a progressively decreasing trajectory, and 5.7% showed a dramatic decreasing trajectory. Age, black participants, and antidepression drugs were significantly associated with the "dramatic decrease" trajectory. Elevated NT pro-BNP was significantly associated with the "dramatic decrease" trajectory.
Markers of left atrial cardiopathy may have significant implications for early diagnosis and prevention of cognitive impairment.
本研究旨在调查无房颤病史的成年人中心房心肌病标志物与认知功能轨迹之间的关联。
本研究纳入了来自中风地理和种族差异原因（REGARDS）研究的4486名参与者。心房心肌病标志物包括房性早搏和N末端脑钠肽前体（NT pro-BNP）。使用六项筛查工具（SIS）测量认知状态。使用潜在类别增长模型确定认知状态轨迹。
在8年的随访中确定了三种独特的认知轨迹：86.7%的人SIS评分显示正常且稳定的轨迹，7.6%的人显示逐渐下降的轨迹，5.7%的人显示急剧下降的轨迹。年龄、黑人参与者和抗抑郁药物与“急剧下降”轨迹显著相关。NT pro-BNP升高与“急剧下降”轨迹显著相关。
左心房心肌病标志物可能对认知障碍的早期诊断和预防具有重要意义。
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