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遗传学与社会经济地位:关于作用机制的一些初步证据

Genetics and Socioeconomic Status: Some Preliminary Evidence on Mechanisms.

作者信息

Carvalho Leandro S

机构信息

University of Southern California, Center for Economic and Social Research, 635 Downey Way, Los Angeles, CA 90089-3332.

出版信息

J Polit Econ Microecon. 2025 Aug;3(3). doi: 10.1086/732835. Epub 2025 Jul 16.

DOI:10.1086/732835
PMID:40894263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12396734/
Abstract

Does genetics influence one's economic prospects? I exploit randomness in the genetic transmission from parents to offspring to estimate causal genetic effects. The genetic measure is the polygenic index (PGI) for educational attainment. High-PGI individuals have higher incomes, largely because of their schooling and occupational choices: They get more education and sort into better-paying occupations. Genetics seems to drive individual differences in the marginal benefits and costs of schooling. The evidence fluid intelligence and self-control partly mediate the relationship between the PGI and education. Genetic effects are economically meaningful, comparable in size to effects of family environment.

摘要

基因会影响一个人的经济前景吗?我利用父母与子女之间基因传递的随机性来估计基因的因果效应。基因测量指标是教育成就的多基因指数(PGI)。高PGI的个体收入更高,这主要是由于他们的受教育程度和职业选择:他们接受了更多教育,并进入了收入更高的职业。基因似乎导致了个体在上学的边际收益和成本方面的差异。有证据表明,流体智力和自我控制在一定程度上调节了PGI与教育之间的关系。基因效应在经济上具有重要意义,其大小与家庭环境的影响相当。

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本文引用的文献

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Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates.在校正全基因组关联研究中的志愿者偏差后,单核苷酸多态性效应大小和遗传力估计值会增加。
Nat Commun. 2025 Apr 15;16(1):3578. doi: 10.1038/s41467-025-58684-8.
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PLoS One. 2024 Feb 15;19(2):e0282212. doi: 10.1371/journal.pone.0282212. eCollection 2024.
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DISTRIBUTIONAL EFFECTS OF EDUCATION ON HEALTH.教育对健康的分布效应。
J Hum Resour. 2023 Jul;58(4):1273-1306. doi: 10.3368/jhr.59.2.0720-11064r1. Epub 2021 Jun 9.
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Sibling variation in polygenic traits and DNA recombination mapping with UK Biobank and IVF family data.多基因性状的同胞间变异及利用 UK Biobank 和 IVF 家族数据进行 DNA 重组作图。
Sci Rep. 2023 Jan 7;13(1):376. doi: 10.1038/s41598-023-27561-z.
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Evaluating indirect genetic effects of siblings using singletons.利用单胎评估同胞的间接遗传效应。
PLoS Genet. 2022 Jul 7;18(7):e1010247. doi: 10.1371/journal.pgen.1010247. eCollection 2022 Jul.
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Mendelian imputation of parental genotypes improves estimates of direct genetic effects.孟德尔基因型推断可提高直接遗传效应的估计值。
Nat Genet. 2022 Jun;54(6):897-905. doi: 10.1038/s41588-022-01085-0. Epub 2022 Jun 9.
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Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.在 300 万人的全基因组关联分析中,对家庭内和家庭间的受教育程度进行多基因预测。
Nat Genet. 2022 Apr;54(4):437-449. doi: 10.1038/s41588-022-01016-z. Epub 2022 Mar 31.
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Resource profile and user guide of the Polygenic Index Repository.多基因风险指数知识库资源简介和用户指南。
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