He Ping, Hu Fangqi, Wang Le
Department of Pediatrics, Anqing Municipal Hospital, Anqing, Anhui, China.
Front Pediatr. 2025 Aug 14;13:1607826. doi: 10.3389/fped.2025.1607826. eCollection 2025.
The causes of children aerophagia are complex, and the treatment methods are diverse. Moreover, it is prone to recurrent attacks. Simethicone oil, as a safe and new type of drug, can be used for treatment.To evaluate the clinical efficacy of simethicone combined with bifidobacterium for the treatment of pediatric aerophagia.
This study evaluated two treatment approaches for aerophagia. The control group received monotherapy with Bifidobacterium, while the treatment group received combination therapy with Bifidobacterium and simethicone. Clinical efficacy, gastrointestinal symptom scores (GSRS), gastric motility parameters, and adverse events were compared between the two groups.
Among the 80 children with aerophagia, 14 (17.5%) were preschool children, 56 (70%) were school-aged children and 10 (12.5%) were adolescents children. Seventy children (87.5%) had abdominal distension as their chief complaint. The treatment group exhibited a significantly higher clinical efficacy rate (92.5% vs. 75%, < 0.05) and lower post-treatment GSRS scores ( < 0.05). Gastric emptying rates at 60 and 120 min were also significantly improved in the treatment group ( < 0.05), although no significant differences were observed in the serum gastrin or plasma motilin levels ( > 0.05).The rate of adverse events was 7.5% in the treatment group and 15% in the control group, with no statistically significant difference ( > 0.05).
The combination of simethicone and bifidobacterium enhances gastric emptying, alleviates the clinical symptoms of pediatric aerophagia, and demonstrates favorable safety and tolerability, thereby supporting its clinical application.
儿童吞气症病因复杂，治疗方法多样，且易反复发作。西甲硅油作为一种安全的新型药物可用于治疗。本研究旨在评估西甲硅油联合双歧杆菌治疗儿童吞气症的临床疗效。
本研究评估了两种吞气症治疗方法。对照组采用双歧杆菌单一疗法，治疗组采用双歧杆菌与西甲硅油联合疗法。比较两组的临床疗效、胃肠道症状评分（GSRS）、胃动力参数及不良事件。
80例吞气症患儿中，学龄前儿童14例（17.5%），学龄儿童56例（70%），青少年儿童10例（12.5%）。以腹胀为主诉的患儿70例（87.5%）。治疗组临床有效率显著更高（92.5% 对75%，P<0.05），治疗后GSRS评分更低（P<0.05）。治疗组60分钟和120分钟时的胃排空率也显著改善（P<0.05），但血清胃泌素或血浆胃动素水平无显著差异（P>0.05）。治疗组不良事件发生率为7.5%，对照组为15%，差异无统计学意义（P>0.05）。
西甲硅油与双歧杆菌联合应用可促进胃排空，缓解儿童吞气症临床症状，安全性及耐受性良好，支持其临床应用。
