Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang, Liaoning, China (mainland).
Med Sci Monit. 2024 Jun 22;30:e943972. doi: 10.12659/MSM.943972.
BACKGROUND Simethicone can improve bowel preparation quality, but the optimal timing of oral simethicone before colonoscopy has not been determined. This study aimed to explore the effect of the time interval between oral simethicone and the start of colonoscopy (S-C) on bowel preparation quality. MATERIAL AND METHODS A total of 364 patients undergoing colonoscopy at our department from August 1, 2021 to November 30, 2021 were included in the training cohort, and 420 consecutive patients from December 15, 2021 to January 31, 2022 comprised the validation cohort. They were classified into short and long S-C groups according to the median S-C. Bowel preparation quality evaluated by the Boston Bowel Preparation Scale was compared between the 2 groups. Logistic regression analyses were performed to explore the correlation between S-C and bowel preparation quality, and we explored the effect of run-way time and time of starting colonoscopy on bowel preparation quality. RESULTS In the training cohort, 182 and 182 patients were classified into the short and long S-C groups, respectively; in the validation cohort, 210 and 210 patients were classified into the 2 groups, respectively. In the 2 cohorts, the short S-C group had a significantly higher rate of adequate/excellent bowel preparation than the long S-C group. Logistic regression analyses showed that shorter S-C, shorter run-way time, and colonoscopy in the morning were all correlated with adequate/excellent bowel preparation. CONCLUSIONS Bowel preparation quality may be affected by S-C, run-way time, and time of starting colonoscopy. S-C shortening should be given equal importance as run-way time shortening.
二甲硅油可改善肠道准备质量，但口服二甲硅油与结肠镜检查（S-C）开始时间之间的最佳间隔尚未确定。本研究旨在探讨口服二甲硅油与结肠镜检查开始时间（S-C）间隔对肠道准备质量的影响。
本研究纳入了 2021 年 8 月 1 日至 11 月 30 日在我科行结肠镜检查的 364 例患者为训练队列，2021 年 12 月 15 日至 2022 年 1 月 31 日连续 420 例患者为验证队列。根据 S-C 的中位数将患者分为短 S-C 组和长 S-C 组。比较两组患者波士顿肠道准备量表（Boston Bowel Preparation Scale）评估的肠道准备质量。采用 logistic 回归分析探讨 S-C 与肠道准备质量的相关性，并探讨运行道时间和结肠镜检查开始时间对肠道准备质量的影响。
在训练队列中，182 例患者被分为短 S-C 组，182 例患者被分为长 S-C 组；在验证队列中，210 例患者被分为短 S-C 组，210 例患者被分为长 S-C 组。在两组中，短 S-C 组的肠道准备充分/优秀率均明显高于长 S-C 组。logistic 回归分析显示，S-C 越短、运行道时间越短、结肠镜检查时间在上午与肠道准备充分/优秀呈正相关。
肠道准备质量可能受到 S-C、运行道时间和结肠镜检查开始时间的影响。缩短 S-C 与缩短运行道时间同样重要。
