Kubota Keiko, Kurabayashi Takashi, Tasaki Masanori, Asato Hirotaka, Iida Takuya
Department of Plastic and Reconstructive Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan.
Department of Plastic and Reconstructive Surgery, Japanese Red Cross Ashikaga Hospital, 284-1 Yobe, Ashikaga, Tochigi 326-0843, Japan.
JPRAS Open. 2025 Aug 6;45:454-459. doi: 10.1016/j.jpra.2025.08.004. eCollection 2025 Sep.
We report a rare granulomatous lobular mastitis (GLM) associated with . infection in a 41-year-old woman presenting as a subpectoral abscess. Diagnosis was delayed due to negative routine cultures and atypical presentation. Surgical excision combined with long-term levofloxacin therapy achieved full recovery. Effective treatment requires antimicrobial coverage and elimination of static secretions in the mammary gland to prevent recurrence. Our case presents a unique perspective by illustrating how , a facultative intracellular pathogen that targets macrophages and other immune cells, may secondarily infect a GLM lesion, characterized by dense infiltration of immune cells.
我们报告了一例罕见的肉芽肿性小叶性乳腺炎（GLM），与感染相关，发生在一名41岁表现为胸肌下脓肿的女性身上。由于常规培养结果为阴性且临床表现不典型，诊断有所延迟。手术切除联合长期左氧氟沙星治疗实现了完全康复。有效的治疗需要抗菌覆盖并清除乳腺中的静态分泌物以防止复发。我们的病例通过说明一种靶向巨噬细胞和其他免疫细胞的兼性细胞内病原体如何继发感染以免疫细胞密集浸润为特征的GLM病变，呈现了一个独特的视角。
