前列腺癌中的RAC1信号传导：VAV鸟苷酸交换因子成为焦点。 - Suppr

RAC1 signaling in prostate cancer: VAV GEFs take center stage.

作者信息

Cooke Mariana, Peinetti Nahuel, Kazanietz Marcelo G, Burnstein Kerry L

机构信息

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, United States.

出版信息

Front Cell Dev Biol. 2025 Aug 15;13:1658639. doi: 10.3389/fcell.2025.1658639. eCollection 2025.

DOI:10.3389/fcell.2025.1658639

PMID:40894927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12395747/

Abstract

摘要

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RAC1 signaling in prostate cancer: VAV GEFs take center stage.

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本文引用的文献

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7.

Int J Biol Sci. 2025 Apr 9;21(6):2843-2863. doi: 10.7150/ijbs.109271. eCollection 2025.

VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer.

Mol Cancer Res. 2025 Aug 4;23(8):684-698. doi: 10.1158/1541-7786.MCR-24-0957.

VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases.

Trends Immunol. 2024 Aug;45(8):580-596. doi: 10.1016/j.it.2024.06.004. Epub 2024 Jul 26.

Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis.

J Biol Chem. 2023 Aug;299(8):104983. doi: 10.1016/j.jbc.2023.104983. Epub 2023 Jun 28.

Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.

Cancer Res Commun. 2022 Dec;2(12):1711-1726. doi: 10.1158/2767-9764.crc-22-0303. Epub 2022 Dec 29.

Nonredundant Rac-GEF control of actin cytoskeleton reorganization.

Trends Cell Biol. 2022 Oct;32(10):815-818. doi: 10.1016/j.tcb.2022.06.003. Epub 2022 Jun 23.

Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.

Brain. 2022 Dec 19;145(12):4232-4245. doi: 10.1093/brain/awac049.

FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.

Cell Rep. 2021 Nov 2;37(5):109905. doi: 10.1016/j.celrep.2021.109905.

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.

Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28.

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RAC1 signaling in prostate cancer: VAV GEFs take center stage.

作者信息

Cooke Mariana, Peinetti Nahuel, Kazanietz Marcelo G, Burnstein Kerry L

机构信息

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, United States.

出版信息

Front Cell Dev Biol. 2025 Aug 15;13:1658639. doi: 10.3389/fcell.2025.1658639. eCollection 2025.

DOI:10.3389/fcell.2025.1658639

PMID:40894927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12395747/

Abstract

摘要

相似文献

RAC1 signaling in prostate cancer: VAV GEFs take center stage.

Front Cell Dev Biol. 2025 Aug 15;13:1658639. doi: 10.3389/fcell.2025.1658639. eCollection 2025.

VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer.

Mol Cancer Res. 2025 Aug 4;23(8):684-698. doi: 10.1158/1541-7786.MCR-24-0957.

Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.

Mol Cell Biol. 2006 Jul;26(13):4830-42. doi: 10.1128/MCB.02215-05.

Vav2 is an activator of Cdc42, Rac1, and RhoA.

J Biol Chem. 2000 Apr 7;275(14):10141-9. doi: 10.1074/jbc.275.14.10141.

The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration.

J Biol Chem. 2020 Aug 14;295(33):11559-11571. doi: 10.1074/jbc.RA119.010925. Epub 2020 Jun 19.

Cell migration signaling through the EGFR-VAV2-Rac1 pathway is sustained in endosomes.

J Cell Sci. 2025 Jan 15;138(2). doi: 10.1242/jcs.263541. Epub 2025 Jan 24.

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

Sci Signal. 2012 Oct 2;5(244):ra71. doi: 10.1126/scisignal.2002962.

Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.

Biochemistry. 2005 May 3;44(17):6573-85. doi: 10.1021/bi047443q.

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.

Mol Biol Cell. 2005 May;16(5):2207-17. doi: 10.1091/mbc.e04-10-0904. Epub 2005 Feb 23.

Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.

Cancer Res. 2012 Jun 15;72(12):3000-9. doi: 10.1158/0008-5472.CAN-11-2502. Epub 2012 Jun 1.

本文引用的文献

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7.

Int J Biol Sci. 2025 Apr 9;21(6):2843-2863. doi: 10.7150/ijbs.109271. eCollection 2025.

VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer.

Mol Cancer Res. 2025 Aug 4;23(8):684-698. doi: 10.1158/1541-7786.MCR-24-0957.

VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases.

Trends Immunol. 2024 Aug;45(8):580-596. doi: 10.1016/j.it.2024.06.004. Epub 2024 Jul 26.

Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis.

J Biol Chem. 2023 Aug;299(8):104983. doi: 10.1016/j.jbc.2023.104983. Epub 2023 Jun 28.

Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.

Cancer Res Commun. 2022 Dec;2(12):1711-1726. doi: 10.1158/2767-9764.crc-22-0303. Epub 2022 Dec 29.

Nonredundant Rac-GEF control of actin cytoskeleton reorganization.

Trends Cell Biol. 2022 Oct;32(10):815-818. doi: 10.1016/j.tcb.2022.06.003. Epub 2022 Jun 23.

Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.

Brain. 2022 Dec 19;145(12):4232-4245. doi: 10.1093/brain/awac049.

FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.

Cell Rep. 2021 Nov 2;37(5):109905. doi: 10.1016/j.celrep.2021.109905.

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.

Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28.

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis.

Biomedicines. 2021 Jun 19;9(6):695. doi: 10.3390/biomedicines9060695.

RAC1 signaling in prostate cancer: VAV GEFs take center stage.

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RAC1 signaling in prostate cancer: VAV GEFs take center stage.

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