RAC1 signaling in prostate cancer: VAV GEFs take center stage.

作者信息

Cooke Mariana, Peinetti Nahuel, Kazanietz Marcelo G, Burnstein Kerry L

机构信息

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, United States.

出版信息

Front Cell Dev Biol. 2025 Aug 15;13:1658639. doi: 10.3389/fcell.2025.1658639. eCollection 2025.

DOI:10.3389/fcell.2025.1658639

PMID:40894927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12395747/

Abstract

摘要

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本文引用的文献

[1]

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7.

Int J Biol Sci. 2025-4-9

[2]

VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer.

Mol Cancer Res. 2025-8-4

[3]

VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases.

Trends Immunol. 2024-8

[4]

Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis.

J Biol Chem. 2023-8

[5]

Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.

Cancer Res Commun. 2022-12

[6]

Nonredundant Rac-GEF control of actin cytoskeleton reorganization.

Trends Cell Biol. 2022-10

[7]

Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.

Brain. 2022-12-19

[8]

FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.

Cell Rep. 2021-11-2

[9]

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.

Leukemia. 2022-3

[10]

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis.

Biomedicines. 2021-6-19

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RAC1 signaling in prostate cancer: VAV GEFs take center stage.

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