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一名9岁女孩异位卵巢上的混合性生殖细胞肿瘤:一例罕见且复杂的病例。

Mixed germ cell tumor on an ectopic ovary with in a 9-year-old girl: A rare and complex case.

作者信息

Abourak Chaimae, Oukassem Siham, Zouita Wadie, Bougrine Imade, Bouljrouf Jaouad, Belkouchi Lina, Allali Nazik, Kisra Mounir, Chat Latifa, El Haddad Siham

机构信息

Department of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

Department of Surgery, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

出版信息

Radiol Case Rep. 2025 Aug 18;20(11):5594-5599. doi: 10.1016/j.radcr.2025.07.047. eCollection 2025 Nov.

Abstract

Malignant ovarian germ cell tumors are rare in the pediatric population, particularly in children under ten years of age. We report a unique case of a mixed germ cell tumor, comprising dysgerminoma, mature and immature teratomas, and yolk sac tumor, located on an ectopic ovary, which was discovered following adnexal torsion in a 9-year-old girl with a family history of gynecological cancers. Mixed germ cell tumors present significant diagnostic challenges due to their heterogeneous histological composition and complex biological behavior. The patient's family history of gynecological cancers raises the possibility of an underlying genetic predisposition. This case underscores the importance of a comprehensive approach to pediatric pelvic masses, particularly in patients with a significant family history of cancer. Long-term follow-up is crucial for the early detection of recurrence in complex germ cell tumors.

摘要

恶性卵巢生殖细胞肿瘤在儿童群体中较为罕见,尤其是在10岁以下的儿童中。我们报告了一例独特的混合性生殖细胞肿瘤病例,该肿瘤由无性细胞瘤、成熟和不成熟畸胎瘤以及卵黄囊瘤组成,位于异位卵巢上,是在一名有妇科癌症家族史的9岁女孩发生附件扭转后发现的。混合性生殖细胞肿瘤因其组织学组成异质性和生物学行为复杂而带来重大的诊断挑战。患者的妇科癌症家族史增加了潜在遗传易感性的可能性。该病例强调了对儿童盆腔肿块采取综合方法的重要性,特别是对于有显著癌症家族史的患者。长期随访对于早期发现复杂生殖细胞肿瘤的复发至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aede/12395979/9d0890709b8a/gr2.jpg

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