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儿童泌乳素分泌型大腺瘤内的垂体卒中:一种罕见的临床实体及其影像学关联。

Pituitary apoplexy within a prolactin-secreting macroadenoma in a child: A rare clinical entity with radiological correlation.

作者信息

Mouhcine Y, Lahjouji O, Ouazzani H, Chaouche I, Akammar A, Bouardi N El, Alami B, Lamrani Y Alaoui, Maaroufi M, Boubbou M

机构信息

Department of Mother and Child Radiology-Chu Hassan Ii, Sidi Mohammed Ben Abdellah University, Hrazem Hospital Center, P.O. Box 1835 Atlas, Fez, Morocco.

Department of Radiology, Chu Hassan Ii, Sidi Mohammed Ben Abdellah University, Hassan II Avenue, Fez 30050, Morocco.

出版信息

Radiol Case Rep. 2025 Aug 16;20(11):5583-5589. doi: 10.1016/j.radcr.2025.07.066. eCollection 2025 Nov.

DOI:10.1016/j.radcr.2025.07.066
PMID:40895003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12390923/
Abstract

Pituitary apoplexy is an uncommon but potentially fatal syndrome of the pituitary gland, caused by ischemia, hemorrhage, or necrosis that can occur with or without a pre-existing pituitary neuroendocrine tumor (PitNET), as reported during pregnancy and in lymphocytic hypophysitis. We present in this paper a case of an 11-year-old girl with pituitary apoplexy. Our patient experienced sudden deterioration in her left eye vision and a headache. The ophthalmological examination reported a divergent strabismus. Brain imaging demonstrated an intra-suprasellar mass with hemorrhagic areas. This paper aims to summarize the key clinical symptoms and typical imaging findings of pituitary apoplexy, with the goal of facilitating early recognition and prompt initiation of appropriate therapy to preserve visual function.

摘要

垂体卒中是一种罕见但可能致命的垂体综合征,由缺血、出血或坏死引起,无论是否存在先前的垂体神经内分泌肿瘤(PitNET)均可发生,如在妊娠期间和淋巴细胞性垂体炎中所报道的那样。我们在本文中介绍了一例11岁患有垂体卒中的女孩。我们的患者左眼视力突然下降并伴有头痛。眼科检查报告为外斜视。脑部影像学检查显示鞍上有一个伴有出血区域的肿块。本文旨在总结垂体卒中的关键临床症状和典型影像学表现,目的是促进早期识别并及时启动适当治疗以保留视觉功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/fa289889a65c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/ca3b1b4f250e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/9c4c60795754/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/fa289889a65c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/ca3b1b4f250e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/9c4c60795754/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff1/12390923/fa289889a65c/gr3.jpg

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Pituitary apoplexy within a prolactin-secreting macroadenoma in a child: A rare clinical entity with radiological correlation.儿童泌乳素分泌型大腺瘤内的垂体卒中:一种罕见的临床实体及其影像学关联。
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本文引用的文献

1
Transnasal Transsphenoidal Approach for a Nine-Year-Old Child With Pituitary Apoplexy: A Case Report.经鼻蝶窦入路治疗一名9岁垂体卒中患儿:病例报告
Cureus. 2024 Jul 14;16(7):e64525. doi: 10.7759/cureus.64525. eCollection 2024 Jul.
2
Pituitary Apoplexy: An Updated Review.垂体卒中:最新综述
J Clin Med. 2024 Apr 24;13(9):2508. doi: 10.3390/jcm13092508.
3
Pituitary apoplexy score, toward standardized decision-making: a descriptive study.垂体卒中评分,旨在实现决策标准化:一项描述性研究。
Pituitary. 2024 Feb;27(1):77-87. doi: 10.1007/s11102-023-01372-x. Epub 2023 Dec 27.
4
Subarachnoid hemorrhage due to pituitary adenoma apoplexy-case report and review of the literature.垂体腺瘤卒中所致蛛网膜下腔出血——病例报告及文献复习
Neurol Sci. 2024 Mar;45(3):997-1005. doi: 10.1007/s10072-023-07130-y. Epub 2023 Oct 23.
5
Natural history of pituitary apoplexy: a long-term follow-up study.垂体卒中的自然病程:一项长期随访研究。
Postgrad Med J. 2023 Jun 15;99(1172):595-598. doi: 10.1136/postgradmedj-2022-141836.
6
Differences in clinical, hormonal, and radiological presentation and in surgical outcomes in patients presenting with and without pituitary apoplexy. A multicenter study of 245 cases.有垂体卒中与无垂体卒中患者的临床、激素和影像学表现及手术结局的差异。一项 245 例患者的多中心研究。
Pituitary. 2023 Apr;26(2):250-258. doi: 10.1007/s11102-023-01315-6. Epub 2023 Apr 27.
7
Pituitary tumour apoplexy within prolactinomas in children: a more aggressive condition?儿童泌乳素瘤中的垂体瘤卒中:一种更具侵袭性的情况?
Pituitary. 2018 Oct;21(5):474-479. doi: 10.1007/s11102-018-0900-8.
8
Clinical and imaging features of pituitary apoplexy and role of imaging in differentiation of clinical mimics.垂体卒中的临床和影像学特征及影像学在鉴别临床模拟疾病中的作用。
Quant Imaging Med Surg. 2018 Mar;8(2):219-231. doi: 10.21037/qims.2018.03.08.
9
Pituitary Adenoma Apoplexy in an Adolescent: A Case Report and Review of the Literature.青少年垂体腺瘤卒中:一例报告及文献复习
J Clin Res Pediatr Endocrinol. 2017 Sep 1;9(3):265-273. doi: 10.4274/jcrpe.4420. Epub 2017 Jun 7.
10
A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report.一例以垂体卒中及颅神经受累为表现的儿童垂体大腺瘤病例报告。
Turk Pediatri Ars. 2016 Sep 1;51(3):162-165. doi: 10.5152/TurkPediatriArs.2016.1945. eCollection 2016 Sep.