Khan Rozi, Yasinzai Abdul Qahar Khan, Goyal Aman, Tracy Katharine, Sohail Amir Humza, Ballur Shalini, Flesner Samuel L, Mahmood Ahmed, Ballur Kalyani, Maheshwari Surabhi, Tareen Tamour Khan, Daoud Mohamed, Sethi Pooja, Alexander Thomas, Ullah Asad
University of Pittsburgh Medical Center, Division of Internal Medicine Harrisburg Pennsylvania USA.
University of Florida Health Cancer Center, Division of Oncology Gainesville Florida USA.
Health Sci Rep. 2025 Aug 27;8(9):e71186. doi: 10.1002/hsr2.71186. eCollection 2025 Sep.
Kaposi sarcoma (KS) is a vascular neoplasm caused by human herpesvirus-8. There is a paucity of data on the cause of death in patients with KS, especially the proportion of cardiovascular mortality. This study aimed to provide annual trends, demographic analysis, and cause of death analysis of KS in the United States.
The Surveillance, Epidemiology, and End Results (SEER) database was used to collect data from 2000 to 2020 from 17 registries.
We identified 8247 patients with KS, with majority males (90.6%) and in the 40-59 age range (38.5%). More than half of the patients were single (53.8%). Hispanic patients constituted 23.9% of the population, while 23.1% were non-Hispanic Black patients. Overall, the incident burden of KS decreased, but there was no significant change in the incident burden of KS among females. Furthermore, no significant change in incident burden was observed among the Hispanic and Black populations. Similarly, annual incident burden among single and never-married individuals has been decreasing since 2014. Patients with KS and primarily cutaneous features (skin KS) have a favorable survival rate compared to those with visceral KS ( < 0.0001). Females, widowed, and Black/American Indian patients had a significantly worse prognosis ( < 0.0001). Married patients had better survival ( < 0.0001). Infectious causes constituted 49.8% of deaths, while 11.4% of deaths were cardiovascular-related. Cardiovascular deaths were significantly more common in females and Hispanic patients ( < 0.001).
Our study provides significant insights into cardiovascular mortality among patients with KS and highlights annual trends, demographic distribution, and mortality rates.
卡波西肉瘤（KS）是一种由人疱疹病毒8型引起的血管性肿瘤。关于KS患者的死因，尤其是心血管疾病死亡率的比例，数据较少。本研究旨在提供美国KS的年度趋势、人口统计学分析及死因分析。
利用监测、流行病学和最终结果（SEER）数据库收集2000年至2020年来自17个登记处的数据。
我们确定了8247例KS患者，其中大多数为男性（90.6%），年龄在40 - 59岁之间（38.5%）。超过一半的患者为单身（53.8%）。西班牙裔患者占总人群的23.9%，而非西班牙裔黑人患者占23.1%。总体而言，KS的发病负担有所下降，但女性KS的发病负担没有显著变化。此外，西班牙裔和黑人人群的发病负担也没有显著变化。同样，自2014年以来，单身和从未结婚者的年度发病负担一直在下降。与内脏型KS患者相比，主要表现为皮肤特征的KS患者（皮肤KS）生存率更高（<0.0001）。女性、丧偶者以及黑人/美洲印第安患者的预后明显更差（<0.0001）。已婚患者生存率更高（<0.0001）。感染性原因占死亡原因的49.8%，而11.4%的死亡与心血管疾病相关。心血管疾病死亡在女性和西班牙裔患者中更为常见（<0.001）。
我们的研究为KS患者的心血管疾病死亡率提供了重要见解，并突出了年度趋势、人口统计学分布和死亡率。
