Hasselbalch H, Junker P, Lisse I, Bentsen K D
Scand J Haematol. 1985 Nov;35(5):550-7. doi: 10.1111/j.1600-0609.1985.tb02827.x.
Using a radioimmunoassay the serum concentration of the N-terminal propeptide of type III procollagen (P-III-P) was measured in 35 patients with chronic myeloproliferative disorders, including idiopathic myelofibrosis (n = 10), osteomyelosclerosis (n = 4), transitional myeloproliferative disorder (n = 5), polycythaemia vera (n = 10) and chronic myelogenous leukaemia (n = 6). The normal range in 35 healthy controls was 4.9-11.7 ng/ml. The serum concentration of P-III-P increased with increasing degrees of bone marrow reticulin fibrosis. By contrast, almost normal levels were detected in osteomyelosclerosis with an indolent clinical course, in which an excessive deposition of mature collagen fibres was found, representing mainly type I collagen. These observations indicate that the serum P-III-P level is positively correlated to the degree of bone marrow reticulin fibrosis, whereas levels are near normal in patients with osteomyelosclerosis and stable disease. Measurement of serum P-III-P may be a useful indicator of disease activity in myelofibrosing conditions.
采用放射免疫分析法，对35例慢性骨髓增殖性疾病患者的血清III型前胶原N端前肽（P-III-P）浓度进行了测定，这些患者包括特发性骨髓纤维化（n = 10）、骨髓硬化症（n = 4）、过渡性骨髓增殖性疾病（n = 5）、真性红细胞增多症（n = 10）和慢性粒细胞白血病（n = 6）。35名健康对照者的正常范围为4.9 - 11.7 ng/ml。P-III-P的血清浓度随骨髓网硬蛋白纤维化程度的增加而升高。相比之下，在临床病程缓慢的骨髓硬化症患者中检测到的水平几乎正常，在这些患者中发现成熟胶原纤维过度沉积，主要为I型胶原。这些观察结果表明，血清P-III-P水平与骨髓网硬蛋白纤维化程度呈正相关，而骨髓硬化症和病情稳定的患者水平接近正常。测定血清P-III-P可能是骨髓纤维化疾病活动的一个有用指标。
