Jacobsen F, Møller-Nielsen C, Mommsen S
Scand J Urol Nephrol. 1985;19(4):253-5. doi: 10.3109/00365598509180265.
A follow-up investigation of 19 patients with carcinoma in situ per se of the urinary bladder (Tis) has been performed. Ten patients developed invasive cancer during a mean observation period of about 4 years. The natural history is unpredictable and therapeutic management of this potentially malignant neoplasm should be individualised. Early radical cystectomy is advocated in selected cases of Tis.
对19例膀胱原位癌（Tis）患者进行了随访调查。在平均约4年的观察期内，有10例患者发展为浸润性癌。其自然病程不可预测，对这种潜在恶性肿瘤的治疗管理应个体化。对于Tis的特定病例，提倡早期根治性膀胱切除术。
