Nakamura Ken, Futagami Seiji, Agawa Shuhei, Higashida Sakura, Tanabe Tomohide, Onda Takeshi, Kawawa Rie, Habiro Mayu, Kirita Kumiko, Sai Songyu, Itokawa Norio, Ueki Nobue, Watanabe Yoshiyuki, Ohta Ryo, Taniai Nobuhiko, Honda Kazufumi, Iwakiri Katsuhiko, Atsukawa Masanori
Division of Gastroenterology Nippon Medical School Tokyo Japan.
Department of Internal Medicine Kawasaki Rinko General Hospital Kawasaki Japan.
DEN Open. 2025 Aug 29;6(1):e70191. doi: 10.1002/deo2.70191. eCollection 2026 Apr.
To evaluate the usefulness of the ELST-blue score to explore its potential application in identifying high-risk groups for early chronic pancreatitis (ECP) through reflecting on pancreatic elasticity and the reduction of pancreatic function, and we tried to demonstrate whether the ELST-blue score was significantly associated with apolipoprotein A2 (apoA2) isoforms in patients with ECP.
Forty-four patients with pancreatic enzyme abnormalities underwent endosonography. We divided two groups, one group was patients with ECP ( = 16) and the other group was patients with non-ECP ( = 28). ELST-blue was defined using the open-source software 'Image J'. The concentration of apoA2 isoforms was measured using an enzyme-linked immunosorbent assay kit.
Epigastric pain tended to be more severe in patients with ECP than in those without ECP. There was a significant difference in the diameter of the main pancreatic duct of more than 2 mm as well as in stranding or hyperechoic foci and lobularity between patients with ECP and non-ECP. The ELST-blue score was significantly higher in patients with ECP than in non-ECP ( = 0.003). Although an intense negative correlation was determined between ELST-blue score and the apoA2-i Index in patients with ECP (r = -0.704, = 0.002), there was no significant relationship between ELST-blue score and apoA2-I Index in patients with non-ECP.
Patients with ECP accompanied by a high score of ELST-blue have to be followed up carefully.
为评估ELST-蓝评分的实用性，通过反映胰腺弹性和胰腺功能减退来探索其在识别早期慢性胰腺炎（ECP）高危人群中的潜在应用，并试图证明ELST-蓝评分与ECP患者的载脂蛋白A2（apoA2）亚型是否存在显著关联。
44例胰腺酶异常患者接受了内镜超声检查。我们将患者分为两组，一组是ECP患者（n = 16），另一组是非ECP患者（n = 28）。使用开源软件“Image J”定义ELST-蓝评分。使用酶联免疫吸附测定试剂盒测量apoA2亚型的浓度。
ECP患者的上腹部疼痛往往比非ECP患者更严重。ECP患者与非ECP患者之间，主胰管直径超过2 mm以及条索状或高回声灶和小叶状方面存在显著差异。ECP患者的ELST-蓝评分显著高于非ECP患者（P = 0.003）。虽然在ECP患者中ELST-蓝评分与apoA2-i指数之间存在强烈的负相关（r = -0.704，P = 0.002），但在非ECP患者中ELST-蓝评分与apoA2-I指数之间没有显著关系。
伴有高ELST-蓝评分的ECP患者必须进行仔细随访。
