Chen Ke-Qian, Cao Wen-Jing, Wang Shu-Zhi, Li Wei
Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China.
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, University of South China, Hengyang, China.
Front Immunol. 2025 Aug 15;16:1655560. doi: 10.3389/fimmu.2025.1655560. eCollection 2025.
With the development of society and the economy, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major chronic disease in contemporary society. Finding a safe, effective, and economical diagnostic method is essential for the prevention of MASLD. Serum immunoglobulin is a protein produced by the B cells after the body is stimulated by an external antigen or pathogen. It is very interesting and valuable to explore the relationship between serum immunoglobulins and MASLD. Unfortunately, only a small number of studies have explored the relationship between serum immunoglobulins and MASLD. Therefore, we review the research progress of serum immunoglobulins in MASLD. At the same time, we also discuss the shortcomings of these studies. We hope this review will provide experience and reference for the prevention of MASLD in the future.
随着社会和经济的发展，代谢功能障碍相关脂肪性肝病（MASLD）已成为当代社会的一种主要慢性病。寻找一种安全、有效且经济的诊断方法对于MASLD的预防至关重要。血清免疫球蛋白是机体受到外部抗原或病原体刺激后由B细胞产生的一种蛋白质。探索血清免疫球蛋白与MASLD之间的关系非常有趣且具有价值。遗憾的是，仅有少数研究探讨了血清免疫球蛋白与MASLD之间的关系。因此，我们综述了血清免疫球蛋白在MASLD中的研究进展。同时，我们也讨论了这些研究的不足之处。我们希望这篇综述能为未来MASLD的预防提供经验和参考。
