Márton Rita, Hermann Hanna, Kiss Virág Tünde, Fenyvesi Éva, Szente Lajos, Molnár Mónika
Department of Applied Biotechnology and Food Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.
CycloLab Cyclodextrin R & D Laboratory Ltd. 1097 Budapest, Hungary.
Biotechnol Rep (Amst). 2025 Aug 9;47:e00912. doi: 10.1016/j.btre.2025.e00912. eCollection 2025 Sep.
The primary objective of this research was to explore the bioactive potential of cyclodextrins in attenuating biofilm formation in . The concentration-dependent effects of both native cyclodextrins and specific derivatives were studied at concentrations ranging from 0.1 to 12.5 mM, to determine the mechanisms by which the extent of biofilm formation can be reduced. Besides, the efficiency of various combinations of cyclodextrins and farnesol, as an antifungal substance, were examined. The present study revealed both stimulatory and inhibitory effects of cyclodextrins on biofilm formation, depending on the structure and concentration. The bioactive potential of randomly methylated α- and γ-CD showed significant antifungal properties, as evidenced by a reduction in the biofilm formation. In addition, randomly methylated cyclodextrins were found to significantly enhance the antifungal activity of farnesol against . Consequently, their synergistic effect may provide an excellent opportunity to produce a lower dose but more effective anticandidal formulation.
本研究的主要目的是探索环糊精在减轻生物膜形成方面的生物活性潜力。研究了天然环糊精及其特定衍生物在0.1至12.5 mM浓度范围内的浓度依赖性效应，以确定可减少生物膜形成程度的机制。此外，还研究了环糊精与作为抗真菌物质的法尼醇的各种组合的效果。本研究揭示了环糊精对生物膜形成的刺激和抑制作用，这取决于其结构和浓度。随机甲基化的α-和γ-环糊精的生物活性潜力显示出显著的抗真菌特性，生物膜形成减少证明了这一点。此外，发现随机甲基化的环糊精可显著增强法尼醇对……的抗真菌活性。因此，它们的协同效应可能为生产低剂量但更有效的抗念珠菌制剂提供绝佳机会。
