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Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control.

作者信息

De La Hoz-Romo María Clara, Díaz Luis, Gómez-León Javier, Reyes Luis Felipe, Quintero Marynes, Villamil Luisa

机构信息

Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia.

Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia.

出版信息

Biotechnol Rep (Amst). 2025 Jun 24;47:e00903. doi: 10.1016/j.btre.2025.e00903. eCollection 2025 Sep.

DOI:10.1016/j.btre.2025.e00903
PMID:40895590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12391250/
Abstract

Quorum sensing (QS) regulates virulence factors in bacteria associated with acne vulgaris. Consequently, extracts from marine actinobacteria sourced from Colombian Caribbean sponges and octocorals were screened for quorum quenching (QQ) and anti-biofilm activity. The most promising extract, G12.218 from sp. CLIVUS-G12218, inhibited QS by 97 % via AI-2 signaling in BB170 and reduced biofilm by 60 % at 3 mg/L, without cytotoxicity to keratinocytes and fibroblasts. Untargeted metabolomics of QQ active and non-active extracts revealed distinct profiles enriched in terpenoids, phenols, and butenolides, potentially linked to bioactivity. These extracts also exhibited antioxidant capacity (18 ± 0.23 µmol TE/L) and hyaluronidase inhibition up to 72.8 %, suggesting skin-protective properties. These findings highlight the potential of marine actinobacteria as a source of QQ and anti-biofilm agents for acne therapy and skincare.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/9f382c327414/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/a7c2c4b0b329/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/e542cfe4dcb4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/e152c367acb8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/3a6ed911c471/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/7e6c25ff21d6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/a6f5c1bff875/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/61ab2bd2726a/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/9f382c327414/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/a7c2c4b0b329/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/e542cfe4dcb4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/e152c367acb8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/3a6ed911c471/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/7e6c25ff21d6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/a6f5c1bff875/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/61ab2bd2726a/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667c/12391250/9f382c327414/gr7.jpg

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[1]
Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control.

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本文引用的文献

[1]
A Clinico-epidemiological study on acne vulgaris with an assessment of its treatment strategies and drug prescribing practices in a tertiary care hospital - an observational study.

Arch Dermatol Res. 2025-3-19

[2]
Marine actinobacteria metabolites: unlocking new treatments for acne vulgaris.

Front Microbiol. 2025-1-6

[3]
New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex.

J Cosmet Dermatol. 2024-11

[4]
Revisiting Fold-Change Calculation: Preference for Median or Geometric Mean over Arithmetic Mean-Based Methods.

Biomedicines. 2024-7-23

[5]
Anti-Biofilm Extracts and Molecules from the Marine Environment.

Mar Drugs. 2024-7-10

[6]
A new topical biotechnological phytocomplex for truncal mild-moderate acne restores skin microbiota balance.

Skin Res Technol. 2024-7

[7]
Heparinoid enhances the efficacy of a bactericidal agent by preventing Cutibacterium acnes biofilm formation via quorum sensing inhibition.

J Microorg Control. 2024

[8]
Anti-Biofilm Activity of Carnosic Acid from against Methicillin-Resistant .

Plants (Basel). 2023-10-25

[9]
Control of pathogenic bacteria using marine actinobacterial extract with antiquorum sensing and antibiofilm activity.

BMC Res Notes. 2023-11-2

[10]
Genome-Scale Metabolic Reconstruction, Non-Targeted LC-QTOF-MS Based Metabolomics Data, and Evaluation of Anticancer Activity of Leaf Extracts.

Metabolites. 2023-6-24

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