El Masadi Mohammed, Elouaouch Sofia, Bouayed Fatima Zahra, BenSghier Ahmed, Berhili Soufiane, Moukhlissi Mohamed, Mezouar Loubna
Radiation Oncology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University of Oujda, Oujda, MAR.
Radiation Oncology, Centre Hospitalier Universitaire Mohammed VI, Oujda, MAR.
Cureus. 2025 Aug 1;17(8):e89193. doi: 10.7759/cureus.89193. eCollection 2025 Aug.
Breast cancer is the most common malignancy among women worldwide and encompasses a wide variety of histopathological subtypes. While invasive ductal carcinoma (IDC) represents the most prevalent form, rare variants such as apocrine carcinoma (AC) also warrant particular attention. Classically, AC of the breast is defined by apocrine morphology, negativity for hormonal receptors (estrogen receptor (ER), progesterone receptor (PR)), and strong positivity for the androgen receptor (AR). However, the present case involving a 37-year-old woman who detected a nodule at the junction of the lower quadrants of the right breast illustrates an atypical variant of this tumor subtype. Histological examination revealed two lesions displaying typical apocrine carcinomatous proliferation but with an unusual immunohistochemical profile: ER expression at 80%, PR expression at 5%, and human epidermal growth factor receptor 2 (HER2) overexpression. This deviation from the classical apocrine profile highlights the biological heterogeneity of these tumors and underscores the importance of thorough characterization to optimize therapeutic management.
乳腺癌是全球女性中最常见的恶性肿瘤，包含多种组织病理学亚型。虽然浸润性导管癌（IDC）是最常见的形式，但诸如大汗腺癌（AC）等罕见变体也值得特别关注。传统上，乳腺大汗腺癌由大汗腺形态、激素受体（雌激素受体（ER）、孕激素受体（PR））阴性以及雄激素受体（AR）强阳性来定义。然而，本病例涉及一名37岁女性，她在右乳房下象限交界处发现一个结节，该病例说明了这种肿瘤亚型的一种非典型变体。组织学检查显示两个病灶呈现典型的大汗腺癌性增殖，但免疫组化结果不寻常：ER表达率为80%，PR表达率为5%，人表皮生长因子受体2（HER2）过表达。这种与经典大汗腺特征的偏差凸显了这些肿瘤的生物学异质性，并强调了全面特征化以优化治疗管理的重要性。
