Sadeghi Morteza, Afshari Mahvash, Oh Jin Pyo, Ryu Tae Ho, Choi Hye Ran, Jang Ha Na, Kim Gi Jun, Lee Sanghyeob
Biochemistry, Sa.C. Islamic Azad University, Sanandaj, IRN.
Bioresource Engineering, Sejong University, Seoul, KOR.
Cureus. 2025 Aug 1;17(8):e89199. doi: 10.7759/cureus.89199. eCollection 2025 Aug.
Background Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose regulation and insulin resistance and frequently accompanied by obesity and dyslipidemia. The search for novel therapeutic agents to manage these metabolic parameters remains ongoing. Pepper fruit (cv. ) extract, a non-pungent variant, has been proposed as a potential intervention for metabolic dysfunctions associated with T2D. Methods This study investigated the impact of pepper fruit extract on metabolic parameters using a diabetic mouse model. Fifty mice were randomly assigned to five groups (n = 10 per group): a normal control group, a diabetic control group (), a positive control group treated with acarbose (50 mg/kg), and two treatment groups receiving either 150 mg/kg or 300 mg/kg of "" extract. The intervention lasted for 10 weeks. Key metabolic indicators, including body weight, blood glucose levels, oral glucose tolerance (OGTT), lipid profile (triglycerides and cholesterol), and insulin concentrations, are measured to assess the extract's therapeutic potential. Results Treatment with "" extract resulted in significant reductions in body weight, with the 300 mg/kg group exhibiting a 10.6% decrease compared to the diabetic control. Both treatment groups demonstrated reductions in blood glucose, with the 150 mg/kg group showing statistically significant improvements. OGTT results did not indicate significant enhancement in glucose tolerance, and lipid profiles, including triglyceride and cholesterol levels, did not show significant changes following extract administration. Notably, the extract exerted a marked effect on insulin levels: while the diabetic control group showed hyperinsulinemia, insulin concentrations in the extract-treated groups were significantly reduced, with the 300 mg/kg group achieving a 38% decrease, indicative of improved insulin sensitivity. Conclusion These findings suggest that '' extract may have potential for managing obesity and improving insulin sensitivity in T2D. Importantly, no significant effects on OGTT or lipid profiles were observed in this study. Further research is necessary to clarify the extract's effects on glucose metabolism and lipid regulation.
背景 2 型糖尿病（T2D）是一种复杂的代谢紊乱疾病，其特征为葡萄糖调节受损和胰岛素抵抗，常伴有肥胖和血脂异常。寻找用于管理这些代谢参数的新型治疗药物的工作仍在进行中。甜椒果实（品种 ）提取物，一种不辣的 变种，已被提议作为对与 T2D 相关的代谢功能障碍的潜在干预措施。方法 本研究使用 糖尿病小鼠模型研究了甜椒果实提取物对代谢参数的影响。50 只小鼠被随机分为五组（每组 n = 10）：正常对照组、糖尿病对照组（ ）、用阿卡波糖（50 mg/kg）治疗的阳性对照组，以及两个分别接受 150 mg/kg 或 300 mg/kg “ ”提取物的治疗组。干预持续 10 周。测量包括体重、血糖水平、口服葡萄糖耐量（OGTT）、血脂谱（甘油三酯和胆固醇）和胰岛素浓度在内的关键代谢指标，以评估提取物的治疗潜力。结果 用“ ”提取物治疗导致体重显著降低，300 mg/kg 组与糖尿病对照组相比体重下降了 10.6%。两个治疗组的血糖均有所降低，150 mg/kg 组显示出统计学上的显著改善。OGTT 结果未表明葡萄糖耐量有显著提高，并且在给予提取物后，包括甘油三酯和胆固醇水平在内的血脂谱没有显示出显著变化。值得注意的是，提取物对胰岛素水平有显著影响：糖尿病对照组显示高胰岛素血症，而提取物治疗组的胰岛素浓度显著降低，300 mg/kg 组降低了 38%，表明胰岛素敏感性提高。结论 这些发现表明“ ”提取物可能具有管理 T2D 患者肥胖和改善胰岛素敏感性的潜力。重要的是，本研究未观察到对 OGTT 或血脂谱有显著影响。需要进一步研究以阐明提取物对葡萄糖代谢和脂质调节的影响。
