Wegmann A, Glück R, Keller H, Matthieu J M
Schweiz Med Wochenschr. 1985 Dec 7;115(49):1779-81.
At the Swiss Serum and Vaccine Institute, Berne, a highly purified rabies vaccine presenting a high content of effective rabies virus glucoprotein antigen has been developed. The new vaccine is derived from embryonated duck eggs (PDEV). Immunizations performed according to the post-exposure schedule recommended for potent rabies vaccines by the WHO (6 injections on days 0, 3, 7, 14, 28 and 90) already induce protective antibody titers on day 14 (greater than 1 IU/ml). Use of the latest radioimmunological methods did not reveal the presence of myelin basic protein in the new rabies vaccine. Due to improvements of its preparation the rabies vaccine PDEV is an economical and highly efficient vaccine involving only a very remote risk of post-vaccinal encephalitis.
在伯尔尼的瑞士血清与疫苗研究所，已研制出一种高纯度狂犬病疫苗，其有效狂犬病病毒糖蛋白抗原含量很高。这种新疫苗源自鸭胚（PDEV）。按照世界卫生组织针对高效狂犬病疫苗推荐的暴露后接种程序（在第0、3、7、14、28和90天各接种1剂，共6剂）进行免疫接种，在第14天即可诱导产生保护性抗体滴度（大于1国际单位/毫升）。采用最新的放射免疫方法未在新狂犬病疫苗中检测到髓鞘碱性蛋白。由于制备工艺的改进，PDEV狂犬病疫苗是一种经济高效的疫苗，接种后发生脑炎的风险极低。
