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在私人牙科诊所中管理布加综合征:基于病例的结构化综述

Managing Brugada Syndrome in a Private Dental Practice: A Structured Case-Based Review.

作者信息

Valente Francesco, Gerboni Giacomo, Valente Pierluigi, Sbrenna Lapo, Sbrenna Andrea

机构信息

Oral Implantology, San Damiano Dental Clinic, Rome, ITA.

Oral Medicine, San Damiano Dental Clinic, Rome, ITA.

出版信息

Cureus. 2025 Jul 29;17(7):e88977. doi: 10.7759/cureus.88977. eCollection 2025 Jul.

Abstract

Brugada syndrome (BrS) is a rare inherited cardiac condition associated with a heightened risk of malignant arrhythmias, particularly during exposure to various pharmacological agents, including certain local anesthetics with sodium channel-blocking properties. This condition often generates significant concern among dental professionals, as the routine use of local anesthetics raises uncertainty about safety protocols and perceived medico-legal risks, frequently leading to patient refusal. The result is a silent yet systematic exclusion of these patients from standard pathways of care, with implications that extend beyond the clinical domain to encompass ethical, deontological, and social dimensions. We report the case of a 29-year-old male with BrS and a subcutaneous implantable cardioverter-defibrillator who underwent a conservative restorative dental procedure in a private outpatient clinic. Given the potential risk of arrhythmia during anesthetic infiltration, 4% articaine with epinephrine 1:100,000 was administered slowly and at the minimum effective dose under continuous cardiologic supervision, with real-time ECG and vital sign monitoring initiated prior to injection and maintained throughout the session. The treatment was completed uneventfully, with no ECG abnormalities observed. While limited to a single observation, this case illustrates that, under carefully controlled conditions and with appropriate precautions, outpatient dental management of patients with BrS may be considered a viable option in selected cases. This report includes a brief review of the literature and a focused discussion on the medico-legal implications to contextualize this case and support safe, ethical, and reproducible clinical decision-making in similar outpatient settings.

摘要

Brugada综合征(BrS)是一种罕见的遗传性心脏疾病,与恶性心律失常风险增加相关,尤其是在接触各种药物时,包括某些具有钠通道阻滞特性的局部麻醉剂。这种情况常常引起牙科专业人员的极大关注,因为局部麻醉剂的常规使用增加了安全协议和感知到的医疗法律风险的不确定性,经常导致患者拒绝。结果是这些患者被默默地、系统性地排除在标准护理途径之外,其影响不仅限于临床领域,还涉及伦理、道义和社会层面。我们报告了一例29岁患有BrS且植入皮下植入式心律转复除颤器的男性患者,他在一家私人门诊诊所接受了保守的修复性牙科手术。鉴于麻醉浸润期间心律失常的潜在风险,在持续心脏监护下,缓慢且以最低有效剂量给予含1:100,000肾上腺素的4%阿替卡因,在注射前启动实时心电图和生命体征监测并在整个手术过程中持续监测。治疗顺利完成,未观察到心电图异常。虽然仅限于单一观察,但该病例表明,在仔细控制的条件下并采取适当预防措施,BrS患者的门诊牙科管理在某些选定病例中可被视为一种可行的选择。本报告包括对文献的简要回顾以及对医疗法律影响的重点讨论,以将该病例置于背景中,并支持在类似门诊环境中进行安全、符合伦理且可重复的临床决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def2/12393005/1bc9ed705472/cureus-0017-00000088977-i01.jpg

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本文引用的文献

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Cureus. 2024 Aug 15;16(8):e66963. doi: 10.7759/cureus.66963. eCollection 2024 Aug.
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