Vutthikraivit Wasawat, Rattanawong Pattara, Putthapiban Prapaipan, Sukhumthammarat Weera, Vathesatogkit Prin, Ngarmukos Tachapong, Thakkinstian Ammarin
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Tx.
University of Hawaii Internal Medicine Residency Program, Honolulu, HI.
Acta Cardiol Sin. 2018 May;34(3):267-277. doi: 10.6515/ACS.201805_34(3).20180302B.
Brugada syndrome (BrS) is considered to be an inherited arrhythmic disease associated with fatal complications and premature sudden unexpected death. The prevalence of the Brugada electrocardiogram pattern (BrP) has been reported in several countries. Nonetheless, the specific worldwide prevalence of BrS has not been reported.
We estimated the worldwide prevalence of BrS and Type-2/3 BrP in general adult populations using a systematic review and meta-analysis of the existing literature.
We thoroughly searched MEDLINE and SCOPUS databases up to March 2017. Included studies were population-based electrocardiogram studies in which prevalence was presented or could be calculated from available data. Pooled prevalence by country/region and/or ethnicity was estimated using a random-effect model.
Twenty-eight articles with atotal population of 369,068 were included in this study. The worldwide pooled prevalence of BrS was 0.5 per 1,000 [95% confidence interval (CI): 0.3-0.7]. The highest prevalence was reported in Southeast Asia (1.8 per 1,000, 95% CI: 0.5-6.6); the lowest was found in North Africa (0 per 1,000). BrS in Asians was nine times more common than in Caucasians and 36 times more common than in Hispanics. The worldwide pooled prevalence of Type-2/3 BrP was 6.1 per 1,000 (95% CI: 5.0-7.1). The highest prevalence was also reported in Southeast Asia (35.5 per 1,000, 95% CI: 17.1-53.9).
This study revealed a significant difference in the worldwide prevalence of BrS and Type-2/3 BrP. Brugada electrocardiogram patterns are highly prevalent in Southeast Asia.
布加综合征（BrS）被认为是一种遗传性心律失常疾病，与致命并发症和过早的意外猝死有关。布加心电图模式（BrP）在多个国家的患病率已有报道。然而，BrS在全球的具体患病率尚未见报道。
我们通过对现有文献进行系统评价和荟萃分析，估计一般成年人群中BrS和2/3型BrP在全球的患病率。
我们全面检索了截至2017年3月的MEDLINE和SCOPUS数据库。纳入的研究为基于人群的心电图研究，其中报道了患病率或可根据现有数据计算患病率。使用随机效应模型估计按国家/地区和/或种族划分的合并患病率。
本研究纳入了28篇文章，总样本量为369,068。BrS在全球的合并患病率为每1000人中有0.5例[95%置信区间（CI）：0.3 - 0.7]。东南亚地区的患病率最高（每1000人中有1.8例，95% CI：0.5 - 6.6）；北非地区的患病率最低（每1000人中有0例）。亚洲人患BrS的几率是白种人的9倍，是西班牙裔的36倍。2/3型BrP在全球的合并患病率为每1000人中有6.1例（95% CI：5.0 - 7.1）。患病率最高的地区同样是东南亚（每1000人中有35.5例，95% CI：17.1 - 53.9）。
本研究揭示了BrS和2/3型BrP在全球患病率上的显著差异。布加心电图模式在东南亚地区非常普遍。
