Adiat Mojeed, Ravikumar Aparna, Yadav Shivangi, Raphael Riya, Nafees Samraiz, Nair Kailas, Chohan Muhammad Tahir
Endocrinology, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.
Internal Medicine, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.
Cureus. 2025 Jul 30;17(7):e89047. doi: 10.7759/cureus.89047. eCollection 2025 Jul.
Rhabdomyolysis is caused by the disintegration of skeletal muscle fibres, leading to the release of toxic intracellular components into the systemic circulation resulting from direct or indirect injury to skeletal muscle, and has potential life-threatening complications such as acute renal failure. Drug-induced rhabdomyolysis, a significant subset of this syndrome, is often idiosyncratic in nature, making it challenging to study and predict. Our report explores a case of severe rhabdomyolysis following uncomplicated general anaesthesia for parathyroidectomy in a patient who was on statin therapy perioperatively for 14 years and had relatively no side effects arising from it.
横纹肌溶解症是由骨骼肌纤维解体引起的，由于骨骼肌受到直接或间接损伤，导致有毒的细胞内成分释放到体循环中，并且会引发如急性肾衰竭等潜在的危及生命的并发症。药物性横纹肌溶解症是该综合征的一个重要子集，其本质往往是特异质性的，这使得研究和预测具有挑战性。我们的报告探讨了一例在甲状旁腺切除术中进行简单全身麻醉后发生严重横纹肌溶解症的病例，该患者围手术期接受他汀类药物治疗达14年，且相对未出现副作用。
